Removal of covalently-bound acetylaminofluorene (AAF) from DNA was studied in confluent (non-dividing) control and repair-deficient human fibroblasts. Control fibroblasts and fibroblasts from individuals with Fanconi's anemia and ataxia telangiectasia removed about 50% of the bound AAF in 48 hours. Fibroblasts from individuals with xeroderma pigmentosum (XP) (complementation groups A and C) removed little AAF while XP variants appeared to remove AAF as well as, or almost as well as, control cells.
|Original language||English (US)|
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Jan 10 1977|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology