Removal of acetylaminofluorene from the DNA of control and repair-deficient human fibroblasts

David E. Amacher, Michael W. Lieberman

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Removal of covalently-bound acetylaminofluorene (AAF) from DNA was studied in confluent (non-dividing) control and repair-deficient human fibroblasts. Control fibroblasts and fibroblasts from individuals with Fanconi's anemia and ataxia telangiectasia removed about 50% of the bound AAF in 48 hours. Fibroblasts from individuals with xeroderma pigmentosum (XP) (complementation groups A and C) removed little AAF while XP variants appeared to remove AAF as well as, or almost as well as, control cells.

Original languageEnglish (US)
Pages (from-to)285-290
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume74
Issue number1
DOIs
StatePublished - Jan 10 1977

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Removal of acetylaminofluorene from the DNA of control and repair-deficient human fibroblasts'. Together they form a unique fingerprint.

Cite this