Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields

Mustafa Raoof, Brandon T. Cisneros, Adem Guven, Sophia Phounsavath, Stuart J. Corr, Lon J. Wilson, Steven A. Curley

Research output: Contribution to journalArticlepeer-review

Abstract

The efficacy of nanoparticle-mediated drug delivery is limited by its peri-vascular sequestration, thus necessitating a strategy to trigger drug release from such intra-tumoral nanocarrier-drug depots. In our efforts to explore remotely-activated nanocarriers, we have developed carbon nanocapsules comprised of an ultra-short carbon nanotube shell (US-tubes) loaded with cisplatin (CDDP@US-tubes) and covered with a Pluronic surfactant wrapping to minimize passive release. We demonstrate here that non-invasive radiofrequency (RF) field activation of the CDDP@US-tubes produces heat that causes Pluronic disruption which triggers cisplatin release in an RF-dependent manner. Furthermore, release-dependent cytotoxicity is demonstrated in human hepatocellular carcinoma cell lines.

Original languageEnglish (US)
Pages (from-to)1862-1869
Number of pages8
JournalBiomaterials
Volume34
Issue number7
DOIs
StatePublished - Feb 2013

Keywords

  • Carbon nanotubes
  • Cisplatin
  • Liver cancer
  • Radiofrequency field
  • Triggered release
  • US-tubes

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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