Remote magnetic switch off microgate for nanofluidic drug delivery implants

Marco Farina, Andrea Ballerini, Gianluca Torchio, Giulia Rizzo, Danilo Demarchi, Usha Thekkedath, Alessandro Grattoni

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

In numerous pathologies, implantable drug delivery devices provide advantages over conventional oral or parenteral approaches. Based on the site of implantation and release characteristics, implants can afford either systemic delivery or local administration, whereby the drug is delivered at or near the site of intended action. Unfortunately, current implantable drug delivery systems provide limited options for intervention in the case of an adverse reaction to the drug or the need for dosage adjustment. In the event that drug delivery must be terminated, an urgent surgical retrieval may be the only reliable option. This could be a time sensitive and costly effort, requiring access to trained professionals and emergency medical facilities. To address such limitations, here we demonstrate, in vitro and ex vivo, a novel microsystem for the rapid and effective switch off of drug delivery from an implantable nanofluidic system, by applying a safe external electromagnetic field in the FDA approved dose range. This study represents a proof of concept for a technology with potential for broad applicability to reservoir-based delivery implants for both complete interruption or remote titration of drug administration.

Original languageEnglish (US)
Article number42
JournalBiomedical Microdevices
Volume19
Issue number2
DOIs
StatePublished - Jun 1 2017

Keywords

  • Drug Delivery
  • Electromagnetic field
  • Implantable Device
  • Remote control

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

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