TY - JOUR
T1 - Remote magnetic switch off microgate for nanofluidic drug delivery implants
AU - Farina, Marco
AU - Ballerini, Andrea
AU - Torchio, Gianluca
AU - Rizzo, Giulia
AU - Demarchi, Danilo
AU - Thekkedath, Usha
AU - Grattoni, Alessandro
PY - 2017/6/1
Y1 - 2017/6/1
N2 - In numerous pathologies, implantable drug delivery devices provide advantages over conventional oral or parenteral approaches. Based on the site of implantation and release characteristics, implants can afford either systemic delivery or local administration, whereby the drug is delivered at or near the site of intended action. Unfortunately, current implantable drug delivery systems provide limited options for intervention in the case of an adverse reaction to the drug or the need for dosage adjustment. In the event that drug delivery must be terminated, an urgent surgical retrieval may be the only reliable option. This could be a time sensitive and costly effort, requiring access to trained professionals and emergency medical facilities. To address such limitations, here we demonstrate, in vitro and ex vivo, a novel microsystem for the rapid and effective switch off of drug delivery from an implantable nanofluidic system, by applying a safe external electromagnetic field in the FDA approved dose range. This study represents a proof of concept for a technology with potential for broad applicability to reservoir-based delivery implants for both complete interruption or remote titration of drug administration.
AB - In numerous pathologies, implantable drug delivery devices provide advantages over conventional oral or parenteral approaches. Based on the site of implantation and release characteristics, implants can afford either systemic delivery or local administration, whereby the drug is delivered at or near the site of intended action. Unfortunately, current implantable drug delivery systems provide limited options for intervention in the case of an adverse reaction to the drug or the need for dosage adjustment. In the event that drug delivery must be terminated, an urgent surgical retrieval may be the only reliable option. This could be a time sensitive and costly effort, requiring access to trained professionals and emergency medical facilities. To address such limitations, here we demonstrate, in vitro and ex vivo, a novel microsystem for the rapid and effective switch off of drug delivery from an implantable nanofluidic system, by applying a safe external electromagnetic field in the FDA approved dose range. This study represents a proof of concept for a technology with potential for broad applicability to reservoir-based delivery implants for both complete interruption or remote titration of drug administration.
KW - Drug Delivery
KW - Electromagnetic field
KW - Implantable Device
KW - Remote control
UR - http://www.scopus.com/inward/record.url?scp=85019110550&partnerID=8YFLogxK
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U2 - 10.1007/s10544-017-0180-5
DO - 10.1007/s10544-017-0180-5
M3 - Article
C2 - 28484917
AN - SCOPUS:85019110550
VL - 19
JO - Biomedical Microdevices
JF - Biomedical Microdevices
SN - 1387-2176
IS - 2
M1 - 42
ER -