Reliable low-molecular-weight heparin reversal in a child undergoing emergency surgery: A case report

Mena M. Botros; Mohamed A. Mahmoud; Andrew J. Costandi

doi:10.1016/j.jclinane.2016.04.036

Reliable low-molecular-weight heparin reversal in a child undergoing emergency surgery: A case report

Mena M. Botros, Mohamed A. Mahmoud, Andrew J. Costandi

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Low-molecular-weight heparin neutralization using protamine alone can be unreliable, especially in cases of immediate reversal for emergency surgery. Here, we describe a unique case of a 17-month-old girl with a history of glioneuronal tumor and corresponding hydrocephalus status post debulking and ventriculoperitoneal shunt placement, who was placed on enoxaparin after the development of a sagittal sinus thrombosis. Patient presented for emergency craniectomy and evacuation of subdural bleed after a fall while on therapeutic dose of enoxaparin. Protamine and fresh frozen plasma were used in the patient's perioperative course providing a reliable reversal of enoxaparin.

Original language	English (US)
Pages (from-to)	317-319
Number of pages	3
Journal	Journal of Clinical Anesthesia
Volume	33
DOIs	https://doi.org/10.1016/j.jclinane.2016.04.036
State	Published - Sep 1 2016

Keywords

Enoxaparin
Fresh frozen plasma
LMWH(s)
Low molecular weight heparin
Protamine sulfate

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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10.1016/j.jclinane.2016.04.036

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title = "Reliable low-molecular-weight heparin reversal in a child undergoing emergency surgery: A case report",

abstract = "Low-molecular-weight heparin neutralization using protamine alone can be unreliable, especially in cases of immediate reversal for emergency surgery. Here, we describe a unique case of a 17-month-old girl with a history of glioneuronal tumor and corresponding hydrocephalus status post debulking and ventriculoperitoneal shunt placement, who was placed on enoxaparin after the development of a sagittal sinus thrombosis. Patient presented for emergency craniectomy and evacuation of subdural bleed after a fall while on therapeutic dose of enoxaparin. Protamine and fresh frozen plasma were used in the patient's perioperative course providing a reliable reversal of enoxaparin.",

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AU - Mahmoud, Mohamed A.

AU - Costandi, Andrew J.

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AB - Low-molecular-weight heparin neutralization using protamine alone can be unreliable, especially in cases of immediate reversal for emergency surgery. Here, we describe a unique case of a 17-month-old girl with a history of glioneuronal tumor and corresponding hydrocephalus status post debulking and ventriculoperitoneal shunt placement, who was placed on enoxaparin after the development of a sagittal sinus thrombosis. Patient presented for emergency craniectomy and evacuation of subdural bleed after a fall while on therapeutic dose of enoxaparin. Protamine and fresh frozen plasma were used in the patient's perioperative course providing a reliable reversal of enoxaparin.

KW - Enoxaparin

KW - Fresh frozen plasma

KW - LMWH(s)

KW - Low molecular weight heparin

KW - Protamine sulfate

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Reliable low-molecular-weight heparin reversal in a child undergoing emergency surgery: A case report

Abstract

Keywords

ASJC Scopus subject areas

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