TY - JOUR
T1 - Relationship of aortic valve calcification with coronary artery calcium severity
T2 - The Multi-Ethnic Study of Atherosclerosis (MESA)
AU - Nasir, Khurram
AU - Katz, Ronit
AU - Al-Mallah, Mouaz
AU - Takasu, Junichiro
AU - Shavelle, David M.
AU - Carr, Jeffery J.
AU - Kronmal, Richard
AU - Blumenthal, Roger S.
AU - O'Brien, Kevin
AU - Budoff, Matthew J.
N1 - Funding Information:
This research was supported by R01 HL071739 and contracts N01-HC-95159 through N01-HC-95165 and N01 HC 95169 from the National Heart, Lung, and Blood Institute .
PY - 2010/1
Y1 - 2010/1
N2 - Background: Aortic valve calcification (AVC) and atherosclerosis share causative and pathologic features. Objective: We evaluated the relationship between AVC and coronary artery calcium (CAC) severity in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: Men and women aged 45-84 years (n = 6809; mean age, 62 years) were studied. The presence and burden of AVC and CAC were determined by noncontrast cardiac computed tomography. Relative risk regression was used to model the probability of AVC as a function of CAC > 0 as well as CAC categories (0, 1-99, 100-399, and ≥400) with the reference group being CAC = 0. Results: The prevalence of AVC and CAC was 13% and 50%, respectively. Among those without CAC, the prevalence of AVC was 5% and increased across levels of CAC severity such that 14%, 25%, and 38% had AVC with increasing CAC scores of 1-99, 100-399, and ≥400, respectively (P for trend < 0.0001). After controlling for patient demographic factors and cardiovascular risk factors, the prevalence ratio of AVC among those with mild CAC (1-99) was 1.83 (95% CI, 1.45-2.31) and increased to 3.36 (95% CI, 2.56-4.42) for CAC ≥ 400. Similar statistically significant increased risk of AVC was found when CAC was assessed as a continuous variable. Conclusion: Our study shows that AVC is independently associated with increasing severity of CAC.
AB - Background: Aortic valve calcification (AVC) and atherosclerosis share causative and pathologic features. Objective: We evaluated the relationship between AVC and coronary artery calcium (CAC) severity in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: Men and women aged 45-84 years (n = 6809; mean age, 62 years) were studied. The presence and burden of AVC and CAC were determined by noncontrast cardiac computed tomography. Relative risk regression was used to model the probability of AVC as a function of CAC > 0 as well as CAC categories (0, 1-99, 100-399, and ≥400) with the reference group being CAC = 0. Results: The prevalence of AVC and CAC was 13% and 50%, respectively. Among those without CAC, the prevalence of AVC was 5% and increased across levels of CAC severity such that 14%, 25%, and 38% had AVC with increasing CAC scores of 1-99, 100-399, and ≥400, respectively (P for trend < 0.0001). After controlling for patient demographic factors and cardiovascular risk factors, the prevalence ratio of AVC among those with mild CAC (1-99) was 1.83 (95% CI, 1.45-2.31) and increased to 3.36 (95% CI, 2.56-4.42) for CAC ≥ 400. Similar statistically significant increased risk of AVC was found when CAC was assessed as a continuous variable. Conclusion: Our study shows that AVC is independently associated with increasing severity of CAC.
KW - Aortic valve calcification
KW - Coronary artery calcification
KW - Multi-Ethnic Study of Atherosclerosis
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U2 - 10.1016/j.jcct.2009.12.002
DO - 10.1016/j.jcct.2009.12.002
M3 - Article
C2 - 20159627
AN - SCOPUS:76349096736
SN - 1934-5925
VL - 4
SP - 41
EP - 46
JO - Journal of cardiovascular computed tomography
JF - Journal of cardiovascular computed tomography
IS - 1
ER -