Relationship between Epstein-Barr virus and lymphoepithelioma-like carcinoma of the lung: A clinicopathologic study of 6 cases and review of the literature

Claudia Y. Castro, Mary L. Ostrowski, Roberto Barrios, Linda K. Green, Helmuth H. Popper, Suzanne Zein-Eldin Powell, Philip T. Cagle, Jae Ro

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

Lymphoepithelioma-like carcinoma (LELC) is a rare form of lung cancer, usually encountered in Chinese patients. Similar to nasopharyngeal carcinoma, LELC of the lung is strongly associated with Epstein-Barr virus (EBV) infection in Asian patients, but there is controversy over whether an association exists in patients from Western countries. To determine whether such a relationship exists, we retrospectively studied 6 cases of primary LELC of the lung, all of which were in Western patients. There were 4 men and 2 women, ranging in age from 49 to 75 years. The tumors ranged from 1 to 4.5 cm in diameter. Four patients had stage I disease, 1 had stage IIb disease, and 1 had stage IIIa disease. All patients are alive without evidence of disease with a follow-up of 18 to 30 months. Formalin-fixed, paraffin-embedded tissue was stained with hematoxylin-eosin for routine evaluation and immunostained for keratin and leukocyte common antigen (LCA). LCA staining was performed to exclude large-cell lymphoma. Immunoperoxidase staining (1:500 clone CS1-4; Dako, Carpinteria, CA) and in situ hybridization were performed to detect EBV. Tumors consisted of solid nests of undifferentiated tumor cells in a syncytial arrangement surrounded by heavy lymphoplasmacytic infiltrate. Tumor cells stained positively for keratin but negative for LCA. All 6 cases were negative for EBV, suggesting no association between EBV and LELC in the Western population.

Original languageEnglish (US)
Pages (from-to)863-872
Number of pages10
JournalHuman Pathology
Volume32
Issue number8
DOIs
StatePublished - Jan 1 2001

Keywords

  • Epstein-Barr virus
  • In situ hybridization
  • Lung neoplasm
  • Lymphoepithelioma-like carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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