Relation of serum uric acid with metabolic risk factors in asymptomatic middle-aged Brazilian men

This study in 352 asymptomatic middle-aged Brazilian men demonstrated that serum uric acid increases linearly with an increasing number (0 to ≥3) of metabolic risk factors (5.78 ± 1.1, 6.14 ± 1.0, 6.27 ± 1.1, and 6.79 ± 1.3, p <0.001). In patients who had ≥3 metabolic risk factors, there was a higher prevalence of serum uric acid in the highest quartile (7.2 to 10.3 mg/dl) than in the lowest quartile (2.6 to 5.4 mg/dl, 35% vs 12%, p <0.001). Mean serum levels of uric acid were higher in those who had an abnormal ratio of ≥3 for triglyceride to high-density lipoprotein (suggesting insulin resistance) than in those who had a normal ratio (6.6 ± 1.2 vs 5.87 ± 1 mg/dl, p <0.001).