Relation of family history of premature coronary heart disease and metabolic risk factors to risk of coronary arterial calcium in asymptomatic subjects

Erin D. Michos; Khurram Nasir; John A. Rumberger; Chandra Vasamreddy; Joel B. Braunstein; Matthew J. Budoff; Roger S. Blumenthal

doi:10.1016/j.amjcard.2004.10.045

Relation of family history of premature coronary heart disease and metabolic risk factors to risk of coronary arterial calcium in asymptomatic subjects

Erin D. Michos, Khurram Nasir, John A. Rumberger, Chandra Vasamreddy, Joel B. Braunstein, Matthew J. Budoff, Roger S. Blumenthal

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

We studied 6,141 consecutive, asymptomatic, nondiabetic patients who underwent electron beam tomography and explored the interaction between metabolic risk factors (RFs) and premature family history (FH) of coronary heart disease (CHD) in predicting the presence and severity of coronary arterial calcium (CAC). In the presence of >2 metabolic RFs, patients with a positive FH of premature CHD had a significantly higher prevalence of any CAC, CAC <100, and CAC <75th age-gender percentile than those without a FH of CHD. Our study demonstrated that a familial propensity to subclinical atherosclerosis interacts with the presence of <2 metabolic RFs, magnifying the risks for those exposed to both.

Original language	English (US)
Pages (from-to)	655-657
Number of pages	3
Journal	American Journal of Cardiology
Volume	95
Issue number	5
DOIs	https://doi.org/10.1016/j.amjcard.2004.10.045
State	Published - Mar 1 2005

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.amjcard.2004.10.045

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title = "Relation of family history of premature coronary heart disease and metabolic risk factors to risk of coronary arterial calcium in asymptomatic subjects",

abstract = "We studied 6,141 consecutive, asymptomatic, nondiabetic patients who underwent electron beam tomography and explored the interaction between metabolic risk factors (RFs) and premature family history (FH) of coronary heart disease (CHD) in predicting the presence and severity of coronary arterial calcium (CAC). In the presence of >2 metabolic RFs, patients with a positive FH of premature CHD had a significantly higher prevalence of any CAC, CAC <100, and CAC <75th age-gender percentile than those without a FH of CHD. Our study demonstrated that a familial propensity to subclinical atherosclerosis interacts with the presence of <2 metabolic RFs, magnifying the risks for those exposed to both.",

author = "Michos, {Erin D.} and Khurram Nasir and Rumberger, {John A.} and Chandra Vasamreddy and Braunstein, {Joel B.} and Budoff, {Matthew J.} and Blumenthal, {Roger S.}",

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T1 - Relation of family history of premature coronary heart disease and metabolic risk factors to risk of coronary arterial calcium in asymptomatic subjects

AU - Michos, Erin D.

AU - Nasir, Khurram

AU - Rumberger, John A.

AU - Vasamreddy, Chandra

AU - Braunstein, Joel B.

AU - Budoff, Matthew J.

AU - Blumenthal, Roger S.

PY - 2005/3/1

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AB - We studied 6,141 consecutive, asymptomatic, nondiabetic patients who underwent electron beam tomography and explored the interaction between metabolic risk factors (RFs) and premature family history (FH) of coronary heart disease (CHD) in predicting the presence and severity of coronary arterial calcium (CAC). In the presence of >2 metabolic RFs, patients with a positive FH of premature CHD had a significantly higher prevalence of any CAC, CAC <100, and CAC <75th age-gender percentile than those without a FH of CHD. Our study demonstrated that a familial propensity to subclinical atherosclerosis interacts with the presence of <2 metabolic RFs, magnifying the risks for those exposed to both.

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Relation of family history of premature coronary heart disease and metabolic risk factors to risk of coronary arterial calcium in asymptomatic subjects

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