Related strains of Mycobacterium avium cause disease in children with AIDS and in children with lymphadenitis

Rohan Hazra; Sun Hwa Lee; Joel N. Maslow; Robert N. Husson

doi:10.1086/315378

Related strains of Mycobacterium avium cause disease in children with AIDS and in children with lymphadenitis

Rohan Hazra, Sun Hwa Lee, Joel N. Maslow, Robert N. Husson

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Sequence analysis of the ribosomal internal transcribed spacer of 56 Mycobacterium avium complex isolates from pediatric patients with AIDS or lymphadenitis revealed (similar to the situation in adults) that the closely related Mav-B and Mav-A sequevars caused the vast majority of disease. IS/245 restriction fragment-polymorphism analysis and pulsed-field gel electrophoresis revealed sets of isolates with closely related patterns among strains from patients in the Boston area and among isolates from Los Angeles and Miami patients. The finding of related strains that cause disease in epidemiologically unrelated patients is most consistent with one of two hypotheses: (1) a limited subset of M. avium strains is more virulent and therefore more likely to cause disease in humans, or (2) pathogenic strains are more prevalent in the environment.

Original language	English (US)
Pages (from-to)	1298-1303
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	181
Issue number	4
DOIs	https://doi.org/10.1086/315378
State	Published - 2000

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1086/315378

Cite this

@article{7474802042bb4933ae4404bf64a25664,

title = "Related strains of Mycobacterium avium cause disease in children with AIDS and in children with lymphadenitis",

abstract = "Sequence analysis of the ribosomal internal transcribed spacer of 56 Mycobacterium avium complex isolates from pediatric patients with AIDS or lymphadenitis revealed (similar to the situation in adults) that the closely related Mav-B and Mav-A sequevars caused the vast majority of disease. IS/245 restriction fragment-polymorphism analysis and pulsed-field gel electrophoresis revealed sets of isolates with closely related patterns among strains from patients in the Boston area and among isolates from Los Angeles and Miami patients. The finding of related strains that cause disease in epidemiologically unrelated patients is most consistent with one of two hypotheses: (1) a limited subset of M. avium strains is more virulent and therefore more likely to cause disease in humans, or (2) pathogenic strains are more prevalent in the environment.",

author = "Rohan Hazra and Lee, {Sun Hwa} and Maslow, {Joel N.} and Husson, {Robert N.}",

note = "Funding Information: Financial support: Pediatric AIDS Foundation (PG-50826); Warren-Whitman-Richardson Fellowship of Harvard Medical School and National Institutes of Health training grant (T32AI-07061-22) (both to R.H.).",

year = "2000",

doi = "10.1086/315378",

language = "English (US)",

volume = "181",

pages = "1298--1303",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "4",

}

TY - JOUR

T1 - Related strains of Mycobacterium avium cause disease in children with AIDS and in children with lymphadenitis

AU - Hazra, Rohan

AU - Lee, Sun Hwa

AU - Maslow, Joel N.

AU - Husson, Robert N.

N1 - Funding Information: Financial support: Pediatric AIDS Foundation (PG-50826); Warren-Whitman-Richardson Fellowship of Harvard Medical School and National Institutes of Health training grant (T32AI-07061-22) (both to R.H.).

PY - 2000

Y1 - 2000

N2 - Sequence analysis of the ribosomal internal transcribed spacer of 56 Mycobacterium avium complex isolates from pediatric patients with AIDS or lymphadenitis revealed (similar to the situation in adults) that the closely related Mav-B and Mav-A sequevars caused the vast majority of disease. IS/245 restriction fragment-polymorphism analysis and pulsed-field gel electrophoresis revealed sets of isolates with closely related patterns among strains from patients in the Boston area and among isolates from Los Angeles and Miami patients. The finding of related strains that cause disease in epidemiologically unrelated patients is most consistent with one of two hypotheses: (1) a limited subset of M. avium strains is more virulent and therefore more likely to cause disease in humans, or (2) pathogenic strains are more prevalent in the environment.

AB - Sequence analysis of the ribosomal internal transcribed spacer of 56 Mycobacterium avium complex isolates from pediatric patients with AIDS or lymphadenitis revealed (similar to the situation in adults) that the closely related Mav-B and Mav-A sequevars caused the vast majority of disease. IS/245 restriction fragment-polymorphism analysis and pulsed-field gel electrophoresis revealed sets of isolates with closely related patterns among strains from patients in the Boston area and among isolates from Los Angeles and Miami patients. The finding of related strains that cause disease in epidemiologically unrelated patients is most consistent with one of two hypotheses: (1) a limited subset of M. avium strains is more virulent and therefore more likely to cause disease in humans, or (2) pathogenic strains are more prevalent in the environment.

UR - http://www.scopus.com/inward/record.url?scp=0034099541&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034099541&partnerID=8YFLogxK

U2 - 10.1086/315378

DO - 10.1086/315378

M3 - Article

C2 - 10753729

AN - SCOPUS:0034099541

SN - 0022-1899

VL - 181

SP - 1298

EP - 1303

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 4

ER -

Related strains of Mycobacterium avium cause disease in children with AIDS and in children with lymphadenitis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this