TY - JOUR
T1 - Relapse of escherichia coli meningitis following therapy with moxalactam
AU - Broughton, Robert A.
AU - Mason, Edward
AU - Baker, Carol J.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1982
Y1 - 1982
N2 - Bacteriologic relapse occurred in a premature infant with Escherichia coli K1 meningitis 11 days following the completion of a 3-week course of therapy with the new 1-oxa-beta-lactam antibiotic moxalactam. Therapeutic failure was most probably the result of sequestration of viable bacteria in ventricular and/or paraventricular sites. While in vitro data and preliminary clinical evaluation of the new beta-lactam antibiotics indicate that these agents may be useful in the treatment of neonatal Gram-negative enteric meningitis, undue optimism regarding their efficacy, as with former agents, may be unwarranted.
AB - Bacteriologic relapse occurred in a premature infant with Escherichia coli K1 meningitis 11 days following the completion of a 3-week course of therapy with the new 1-oxa-beta-lactam antibiotic moxalactam. Therapeutic failure was most probably the result of sequestration of viable bacteria in ventricular and/or paraventricular sites. While in vitro data and preliminary clinical evaluation of the new beta-lactam antibiotics indicate that these agents may be useful in the treatment of neonatal Gram-negative enteric meningitis, undue optimism regarding their efficacy, as with former agents, may be unwarranted.
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U2 - 10.1097/00006454-198201000-00007
DO - 10.1097/00006454-198201000-00007
M3 - Article
C2 - 6217454
AN - SCOPUS:0020261051
SN - 0277-9730
VL - 1
SP - 24
EP - 28
JO - Pediatric Infectious Disease
JF - Pediatric Infectious Disease
IS - 1
ER -