Relapse of escherichia coli meningitis following therapy with moxalactam

Robert A. Broughton, Edward Mason, Carol J. Baker

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Bacteriologic relapse occurred in a premature infant with Escherichia coli K1 meningitis 11 days following the completion of a 3-week course of therapy with the new 1-oxa-beta-lactam antibiotic moxalactam. Therapeutic failure was most probably the result of sequestration of viable bacteria in ventricular and/or paraventricular sites. While in vitro data and preliminary clinical evaluation of the new beta-lactam antibiotics indicate that these agents may be useful in the treatment of neonatal Gram-negative enteric meningitis, undue optimism regarding their efficacy, as with former agents, may be unwarranted.

Original languageEnglish (US)
Pages (from-to)24-28
Number of pages5
JournalPediatric Infectious Disease
Issue number1
StatePublished - 1982

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)


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