Regulatory T Cells and Transplantation Tolerance

Shuiping Jiang, Robert I. Lechler, Xiao Shun He, Jie Fu Huang

Research output: Contribution to journalReview article

78 Scopus citations

Abstract

In the past decade, several types of regulatory T cells (Tregs) have been identified to play a pivotal role in the control of autoimmunity and transplantation tolerance in rodents and in human beings, including innate regulatory NKT cells and γδ T cells, naturally occurring FoxP3 expressing CD4+CD25+ T cells, and in-vitro induced Tregs including interleuking-10 (IL-10)-secreting Tr1 CD4+ T cells, TGF-β-producing Th3 CD4+ T cells, anergic CD4+ T cells, CD8+CD28- and CD3+CD4-CD8- T cells. Recent studies have shown that innate and adaptive Tregs may be linked and act in concert to mediate immunosuppression. As our understanding of regulatory T cell populations has substantially advanced, compelling evidence support the prospect that in-vitro expanded, patient-tailored Tregs with indirect anti-donor allospecificity could be potential reagents as adoptive cell therapy for individualized medicine to promote clinical transplantation tolerance.

Original languageEnglish (US)
Pages (from-to)765-776
Number of pages12
JournalHuman Immunology
Volume67
Issue number10
DOIs
StatePublished - Oct 2006

Keywords

  • CD3CD4CD8 T cells
  • CD4CD25 Tregs
  • CD8CD28 T cells
  • FoxP3
  • NKT cells
  • Regulatory T cells
  • Th3
  • Tr1
  • adoptive cell therapy
  • anergic CD4 T cells
  • indirect allospecificity
  • individualized medicine
  • transplantation tolerance
  • γδ T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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