Abstract
In the past decade, several types of regulatory T cells (Tregs) have been identified to play a pivotal role in the control of autoimmunity and transplantation tolerance in rodents and in human beings, including innate regulatory NKT cells and γδ T cells, naturally occurring FoxP3 expressing CD4+CD25+ T cells, and in-vitro induced Tregs including interleuking-10 (IL-10)-secreting Tr1 CD4+ T cells, TGF-β-producing Th3 CD4+ T cells, anergic CD4+ T cells, CD8+CD28- and CD3+CD4-CD8- T cells. Recent studies have shown that innate and adaptive Tregs may be linked and act in concert to mediate immunosuppression. As our understanding of regulatory T cell populations has substantially advanced, compelling evidence support the prospect that in-vitro expanded, patient-tailored Tregs with indirect anti-donor allospecificity could be potential reagents as adoptive cell therapy for individualized medicine to promote clinical transplantation tolerance.
Original language | English (US) |
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Pages (from-to) | 765-776 |
Number of pages | 12 |
Journal | Human Immunology |
Volume | 67 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2006 |
Keywords
- CD3CD4CD8 T cells
- CD4CD25 Tregs
- CD8CD28 T cells
- FoxP3
- NKT cells
- Regulatory T cells
- Th3
- Tr1
- adoptive cell therapy
- anergic CD4 T cells
- indirect allospecificity
- individualized medicine
- transplantation tolerance
- γδ T cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology