TY - JOUR
T1 - Regulation on mechanical properties of collagen
T2 - Enhanced bioactivities of metallofullerol
AU - Song, Yan
AU - Zhang, Mingyi
AU - Zhao, Lina
AU - Yin, Xiaohui
AU - Zhao, Jiaohui
AU - Li, Juan
AU - He, Rui
AU - Chang, Yanan
AU - Jin, Junjiang
AU - Zhao, Yuliang
AU - Li, Jingyuan
AU - Xing, Gengmei
N1 - Funding Information:
This work was supported financially by the National Basic Research Program of China (973 Program No. 2013CB932703, 2012CB932601 and 2013CB933704), National Natural Science Foundation of China (No.21273240). We would like to acknowledge Prof. Ye Tao and other fellow research members at the Beijing Synchrotron Radiation Facility in helping with SRCD (4B8); and we thank Prof. Aiguo Li and other fellow research members at the Shanghai Synchrotron Radiation Facility for their help with the X-ray imaging work (BL15U). We also thank Prof. Ruhong Zhou from IBM Thomas J. Watson Research Center for helpful discussions.
Funding Information:
Statements of funding: National Basic Research Program of China (973 Program No. 2013CB932703, 2012CB932601, 2013CB933704), National Natural Science Foundation of China (No.21273240).
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/5
Y1 - 2014/5
N2 - Increased mechanical property of extracellular matrix (ECM) around tumor tissue is highly correlated to the progression of cancer, and now its efficient regulation is still a challenge. Here, we report that Gd@C82(OH)22-collagen composites greatly suppress the malignant progression of cancer cells in vitro, and the metallofullerol can efficiently reduce the mechanical property of collagen matrix. Further study indicates that Gd@C82(OH)22 can firmly bind to tropocollagen, facilitate the nuclei and microfibril formation. The interference to interactions among tropocollagens leads to decreased amount and disturbed structure of collagen fibers. C60(OH)24, the fullerol counterpart of Gd@C82(OH)22, is studied in parallel and their impacts on collagen are strikingly modest. The comparison data reveals that the enhanced bioactivity of Gd@C82(OH)22 is highly related with its surface-structure. This study is the first attempt to apply nanomedicines to manipulate the biophysical property of collagen matrix, providing a new sight to target ECM in cancer therapy. From the Clinical Editor: Increased presence of "harder" collagen in the extracellular matrix (ECM) around the tumor tissue highly correlates with cancer progression. In this paper, a metallofullerol-based approach is reported as an efficient nanotechnology approach in reducing the mechanical properties of the synthesized collagen, paving the way to the development of novel anti-cancer therapies.
AB - Increased mechanical property of extracellular matrix (ECM) around tumor tissue is highly correlated to the progression of cancer, and now its efficient regulation is still a challenge. Here, we report that Gd@C82(OH)22-collagen composites greatly suppress the malignant progression of cancer cells in vitro, and the metallofullerol can efficiently reduce the mechanical property of collagen matrix. Further study indicates that Gd@C82(OH)22 can firmly bind to tropocollagen, facilitate the nuclei and microfibril formation. The interference to interactions among tropocollagens leads to decreased amount and disturbed structure of collagen fibers. C60(OH)24, the fullerol counterpart of Gd@C82(OH)22, is studied in parallel and their impacts on collagen are strikingly modest. The comparison data reveals that the enhanced bioactivity of Gd@C82(OH)22 is highly related with its surface-structure. This study is the first attempt to apply nanomedicines to manipulate the biophysical property of collagen matrix, providing a new sight to target ECM in cancer therapy. From the Clinical Editor: Increased presence of "harder" collagen in the extracellular matrix (ECM) around the tumor tissue highly correlates with cancer progression. In this paper, a metallofullerol-based approach is reported as an efficient nanotechnology approach in reducing the mechanical properties of the synthesized collagen, paving the way to the development of novel anti-cancer therapies.
KW - Collagen
KW - Mechanical property
KW - Metallofullerol
KW - Structure-related bioactivity
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U2 - 10.1016/j.nano.2013.11.011
DO - 10.1016/j.nano.2013.11.011
M3 - Article
C2 - 24333590
AN - SCOPUS:84900326270
SN - 1549-9634
VL - 10
SP - 783
EP - 793
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
IS - 4
ER -