Regulation of tumor progression and metastasis by bone marrow-derived microenvironments

Tina El Rayes, Dingcheng Gao, Nasser K. Altorki, Thomas R. Cox, Janine T. Erler, Vivek Mittal

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Activating mutations in driver oncogenes and loss-of-function mutations in tumor suppressor genes contribute to tumor progression and metastasis. Accordingly, therapies targeting key tumor cell-intrinsic signaling pathways are being used in clinical trials, and some have met FDA approval. However, these treatments benefit only a small proportion of patients harboring key driver mutations, and acquired resistance to these therapies presents a major impediment to effective treatment. More recently, the contribution of the tumor microenvironment (TME) has been an area of active investigation and has begun to provide critical insights into carcinogenesis. The host stromal cells in the TME coevolve with tumors and contribute to carcinogenesis in several ways. Among the host cells, bone marrow (BM)-derived cells constitute a significant fraction and directly contribute to proliferation, invasion, intravasation, extravasation, and outgrowth at the metastatic site. While the tumor-reprogrammed BM cells constitute attractive targets for anticancer therapy, recent studies have also begun to unravel their role as prognostic and predictive molecular markers of the disease.

Original languageEnglish (US)
Title of host publicationBiomarkers of the Tumor Microenvironment
Subtitle of host publicationBasic Studies and Practical Applications
PublisherSpringer International Publishing
Pages303-328
Number of pages26
ISBN (Electronic)9783319391472
ISBN (Print)9783319391458
DOIs
StatePublished - Aug 2 2017

Keywords

  • Anti-cancer therapy
  • Bone marrow
  • Bone marrow-derived cells
  • Metastasis
  • Pre-metastatic niche
  • Tumor microenvironment
  • Tumor progression

ASJC Scopus subject areas

  • Medicine(all)

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