Regulation of sexual differentiation in drug and steroid metabolism

Peter G. Zaphiropoulos, Agneta Mode, Gunnar Norstedt, Jan Åke Gustafsson

Research output: Contribution to journalReview articlepeer-review

118 Scopus citations


Certain members of the cytochrome P-450 family are expressed at different levels in the livers of male and female rats. Although little is known of the functional significance of these sex differences, progress has been made towards the understanding of the endocrine control of hepatic sex differences in cytochrome P-450 levels. Jan-Åke Gustafsson and colleagues describe a subpopulation of hepatic sexually differentiated P-450s that is regulated by sex differences in growth hormone (GH) secretory pattern. This secretory pattern is in turn regulated by gonadal steroids. These studies demonstrate a novel action of GH and suggest that the hormonal secretory rhythm is pivotal in determination of biological effects.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalTrends in Pharmacological Sciences
Issue number4
StatePublished - Apr 1989

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


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