Regulation of sexual differentiation in drug and steroid             metabolism

Peter G. Zaphiropoulos; Agneta Mode; Gunnar Norstedt; Jan Åke Gustafsson

doi:10.1016/0165-6147(89)90167-3

Regulation of sexual differentiation in drug and steroid metabolism

Peter G. Zaphiropoulos, Agneta Mode, Gunnar Norstedt, Jan Åke Gustafsson

Houston Methodist

Research output: Contribution to journal › Review article › peer-review

128 Scopus citations

Abstract

Certain members of the cytochrome P-450 family are expressed at different levels in the livers of male and female rats. Although little is known of the functional significance of these sex differences, progress has been made towards the understanding of the endocrine control of hepatic sex differences in cytochrome P-450 levels. Jan-Åke Gustafsson and colleagues describe a subpopulation of hepatic sexually differentiated P-450s that is regulated by sex differences in growth hormone (GH) secretory pattern. This secretory pattern is in turn regulated by gonadal steroids. These studies demonstrate a novel action of GH and suggest that the hormonal secretory rhythm is pivotal in determination of biological effects.

Original language	English (US)
Pages (from-to)	149-153
Number of pages	5
Journal	Trends in Pharmacological Sciences
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/0165-6147(89)90167-3
State	Published - Apr 1989

ASJC Scopus subject areas

Toxicology
Pharmacology

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title = "Regulation of sexual differentiation in drug and steroid metabolism",

abstract = "Certain members of the cytochrome P-450 family are expressed at different levels in the livers of male and female rats. Although little is known of the functional significance of these sex differences, progress has been made towards the understanding of the endocrine control of hepatic sex differences in cytochrome P-450 levels. Jan-{\AA}ke Gustafsson and colleagues describe a subpopulation of hepatic sexually differentiated P-450s that is regulated by sex differences in growth hormone (GH) secretory pattern. This secretory pattern is in turn regulated by gonadal steroids. These studies demonstrate a novel action of GH and suggest that the hormonal secretory rhythm is pivotal in determination of biological effects.",

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AU - Mode, Agneta

AU - Norstedt, Gunnar

AU - Gustafsson, Jan Åke

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N2 - Certain members of the cytochrome P-450 family are expressed at different levels in the livers of male and female rats. Although little is known of the functional significance of these sex differences, progress has been made towards the understanding of the endocrine control of hepatic sex differences in cytochrome P-450 levels. Jan-Åke Gustafsson and colleagues describe a subpopulation of hepatic sexually differentiated P-450s that is regulated by sex differences in growth hormone (GH) secretory pattern. This secretory pattern is in turn regulated by gonadal steroids. These studies demonstrate a novel action of GH and suggest that the hormonal secretory rhythm is pivotal in determination of biological effects.

AB - Certain members of the cytochrome P-450 family are expressed at different levels in the livers of male and female rats. Although little is known of the functional significance of these sex differences, progress has been made towards the understanding of the endocrine control of hepatic sex differences in cytochrome P-450 levels. Jan-Åke Gustafsson and colleagues describe a subpopulation of hepatic sexually differentiated P-450s that is regulated by sex differences in growth hormone (GH) secretory pattern. This secretory pattern is in turn regulated by gonadal steroids. These studies demonstrate a novel action of GH and suggest that the hormonal secretory rhythm is pivotal in determination of biological effects.

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Regulation of sexual differentiation in drug and steroid metabolism

Abstract

ASJC Scopus subject areas

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