Regulation of B-cell activation by CD45: a question of mechanism

Louis B. Justement, Vergil K. Brown, Jiejian Lin

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Recent studies have demonstrated that the protein tyrosine phosphatase CD45 plays an integral role in regulation of B-cell function. Most notably, expression of this phosphatase is required for activation of B lymphocytes and entry into the cell cycle. Here, Louis Justement and colleagues review current information concerning the function of CD45 in the B cell. The discussion focuses on two questions that are of central importance: what are the physiological substrates for CD45 and how does reversible tyrosine phosphorylation affect their function?

Original languageEnglish (US)
Pages (from-to)399-406
Number of pages8
JournalImmunology Today
Volume15
Issue number9
DOIs
StatePublished - Sep 1994

ASJC Scopus subject areas

  • Immunology

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