Regulation and functional significance of autophagy in respiratory cell biology and disease

Avignat S. Patel, Danielle Morse, Augustine M.K. Choi

Research output: Contribution to journalReview article

37 Scopus citations

Abstract

Autophagy is a homeostatic process common to all eukaryotic cells that serves to degrade intracellular components. Among three classes of autophagy, macroautophagy is best understood, and is the subject of this Review. The function of autophagy is multifaceted, and includes removal of long-lived proteins and damaged or unneeded organelles, recycling of intracellular components for nutrients, and defense against pathogens. This process has been extensively studied in yeast, and understanding of its functional significance in human disease is also increasing. This Review explores the basic machinery and regulation of autophagy in mammalian systems, methods employed to measure autophagic activity, and then focuses on recent discoveries about the functional significance of autophagy in respiratory diseases, including chronic obstructive pulmonary disease, cystic fibrosis, tuberculosis, idiopathic pulmonary fibrosis, pulmonary arterial hypertension, acute lung injury, and lymphangioleiomyomatosis.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume48
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Autophagy
  • Chronic obstructive pulmonary disease
  • Epithelial cells
  • Fibroblasts
  • Idiopathic pulmonary fibrosis

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology

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