Abstract
It is difficult to directly coregister the 3-D fluorescence molecular tomography (FMT) image of a small tumor in a mouse whose maximal diameter is only a few millimeters with a larger CT image of the entire animal that spans about 10 cm. This paper proposes a new method to register 2-D flat and 3-D CT image first to facilitate the registration between small 3-D FMT images and large 3-D CT images. A novel algorithm combining differential evolution and improved simplex method for the registration between the 2-D flat and 3-D CT images is introduced and validated with simulated images and real images of mice. The visualization of the alignment of the 3-D FMT and CT image through 2-D registration shows promising results.
Original language | English (US) |
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Pages (from-to) | 569-578 |
Number of pages | 10 |
Journal | IEEE Transactions on Information Technology in Biomedicine |
Volume | 12 |
Issue number | 5 |
DOIs | |
State | Published - 2008 |
Keywords
- Animal molecular imaging
- Fluorescence molecular (FMT)
- Registration
- Snake model
ASJC Scopus subject areas
- Health Informatics
- Health Information Management
- Information Systems
- Computer Science Applications
- Computational Theory and Mathematics
- Medicine(all)