Registration of 3-D CT and 2-D flat images of mouse via affine transformation

Zheng Xia, Xishi Huang, Xiaobo Zhou, Youxian Sun, Vasilis Ntziachristos, Stephen T C Wong

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

It is difficult to directly coregister the 3-D fluorescence molecular tomography (FMT) image of a small tumor in a mouse whose maximal diameter is only a few millimeters with a larger CT image of the entire animal that spans about 10 cm. This paper proposes a new method to register 2-D flat and 3-D CT image first to facilitate the registration between small 3-D FMT images and large 3-D CT images. A novel algorithm combining differential evolution and improved simplex method for the registration between the 2-D flat and 3-D CT images is introduced and validated with simulated images and real images of mice. The visualization of the alignment of the 3-D FMT and CT image through 2-D registration shows promising results.

Original languageEnglish (US)
Pages (from-to)569-578
Number of pages10
JournalIEEE Transactions on Information Technology in Biomedicine
Volume12
Issue number5
DOIs
StatePublished - 2008

Keywords

  • Animal molecular imaging
  • Fluorescence molecular (FMT)
  • Registration
  • Snake model

ASJC Scopus subject areas

  • Health Informatics
  • Health Information Management
  • Information Systems
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Medicine(all)

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