Regeneration of the canine urinary bladder mucosa after complete surgical denudation

K. I. Wishnow, D. E. Johnson, D. J. Grignon, D. M. Cromeens, Alberto Ayala

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


To study the site of origin of epithelial regeneration in the urinary bladder after surgical denudation, we completely obliterated the bladder mucosa in 17 dogs, using the neodymium:YAG laser. Bladder-mapping studies showed that the regenerating cells arose from the epithelium of the terminal ureters and urethra. Experimental construction of isolated bladder pouches confirmed these findings and demonstrated that urine flow was not essential for reepithelialization. These results are relevant to the treatment of patients with multifocal carcinoma in sutu of the bladder. Although the entire bladder can be denuded successfully, the studies demonstrate that the procedure might fail if the sources of epithelial regrowth, the distal ureters and urethra, contain untreated carcinoma in situ.

Original languageEnglish (US)
Pages (from-to)1476-1479
Number of pages4
JournalJournal of Urology
Issue number6
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Urology


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