Regeneration of humoral immunity to herpes simplex virus following T‐cell‐depleted allogeneic bone marrow transplantation

J. Z. Wimperis, N. J. Berry, H. Grant Prentice, A. Lever, P. D. Griffiths, M. K. Brenner

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We investigated the adoptive transfer of immunity to herpes simplex virus (HSV) in 61 recipients of T-cell-depleted marrow allografts. Up to 3 months after bone marrow transplantation (BMT), high titres of HSV antibody (Ab) are passively acquired from blood products. This antibody has a half-life of 40.3 days, so that determination of recipient immunity to HSV cannot be made during the early post-transplant period. By 4 months after the allograft, seronegative recipients of seronegative donors had near-background levels of HSV Ab. Seropositive recipients,

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalJournal of Medical Virology
Volume23
Issue number1
DOIs
StatePublished - Sep 1987

Keywords

  • T‐cell depletion
  • immunity transfer
  • marrow transplant
  • viral infections

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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