Regeneration of humoral immunity to herpes simplex virus following T‐cell‐depleted allogeneic bone marrow transplantation

J. Z. Wimperis; N. J. Berry; H. Grant Prentice; A. Lever; P. D. Griffiths; M. K. Brenner

doi:10.1002/jmv.1890230111

Regeneration of humoral immunity to herpes simplex virus following T‐cell‐depleted allogeneic bone marrow transplantation

J. Z. Wimperis, N. J. Berry, H. Grant Prentice, A. Lever, P. D. Griffiths, M. K. Brenner

Research output: Contribution to journal › Article

5 Scopus citations

Abstract

We investigated the adoptive transfer of immunity to herpes simplex virus (HSV) in 61 recipients of T-cell-depleted marrow allografts. Up to 3 months after bone marrow transplantation (BMT), high titres of HSV antibody (Ab) are passively acquired from blood products. This antibody has a half-life of 40.3 days, so that determination of recipient immunity to HSV cannot be made during the early post-transplant period. By 4 months after the allograft, seronegative recipients of seronegative donors had near-background levels of HSV Ab. Seropositive recipients,

Original language	English (US)
Pages (from-to)	93-99
Number of pages	7
Journal	Journal of Medical Virology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1002/jmv.1890230111
State	Published - Sep 1987

Keywords

T‐cell depletion
immunity transfer
marrow transplant
viral infections

ASJC Scopus subject areas

Virology
Infectious Diseases

Access to Document

10.1002/jmv.1890230111

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abstract = "We investigated the adoptive transfer of immunity to herpes simplex virus (HSV) in 61 recipients of T-cell-depleted marrow allografts. Up to 3 months after bone marrow transplantation (BMT), high titres of HSV antibody (Ab) are passively acquired from blood products. This antibody has a half-life of 40.3 days, so that determination of recipient immunity to HSV cannot be made during the early post-transplant period. By 4 months after the allograft, seronegative recipients of seronegative donors had near-background levels of HSV Ab. Seropositive recipients,",

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AU - Wimperis, J. Z.

AU - Berry, N. J.

AU - Prentice, H. Grant

AU - Lever, A.

AU - Griffiths, P. D.

AU - Brenner, M. K.

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AB - We investigated the adoptive transfer of immunity to herpes simplex virus (HSV) in 61 recipients of T-cell-depleted marrow allografts. Up to 3 months after bone marrow transplantation (BMT), high titres of HSV antibody (Ab) are passively acquired from blood products. This antibody has a half-life of 40.3 days, so that determination of recipient immunity to HSV cannot be made during the early post-transplant period. By 4 months after the allograft, seronegative recipients of seronegative donors had near-background levels of HSV Ab. Seropositive recipients,

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