Refractory overactive bladder in men: Update on novel therapies

Casey K. Ng, Ricardo R. Gonzalez, Alexis E. Te

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Overactive bladder (OAB) in men is an entity that may be challenging to diagnose and treat, especially in the presence of bladder outlet obstruction. The application of oral medical treatments of lower urinary tract symptoms attributed to benign prostatic hyperplasia has traditionally utilized α-adrenergic blockers and 5α-reductase inhibitors. After failure of oral medical therapies, surgical options are traditionally offered. Even after surgical options are successful, lower urinary tract symptoms that are secondary to OAB persist. These patients merit a trial of antimuscarinic drugs. Additionally, certain patients with concomitant bladder outlet obstruction who have not been surgically relieved can still merit a trial of antimuscarinic drugs without significant risk of developing urinary retention. When these oral antimuscarinic drugs fail, options still remain for treating men with refractory OAB. Successful application of various diagnostic approaches and the initiation of conservative options as well as other options, such as neuromodulation for refractory urgency and urge incontinence, can help the patient. Finally, emerging data support the use of intradetrusor injections of botulinum toxin for refractory OAB.

Original languageEnglish (US)
Pages (from-to)456-461
Number of pages6
JournalCurrent Urology Reports
Issue number6
StatePublished - Nov 2006

ASJC Scopus subject areas

  • Urology


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