TY - JOUR
T1 - Reference intervals for amylase isoenzymes in serum and plasma of infants and children
AU - Gillard, B. K.
AU - Simbala, J. A.
AU - Goodglick, L.
N1 - Funding Information:
The authors gratefully acknowledge the support from CANDAC funding agencies: ARIF, AIF/NSRIT, CFCAS, CFI, CSA, EC, GOC-IPY, INAC, NSERC, NSTP, OIT, ORF, PCSP, and SEARCH. We thank CANDAC/PEARL PI James R. Drummond, PEARL site manager Pierre Fogal, the CANDAC operators, and Environment Canada Eureka Weather Station staff for logistical and operational support at Eureka. The spring 2011 PEARL-GBS measurements were also supported by the Canadian Arctic ACE Validation Campaigns (Co-PI Kaley Walker), which were funded by Canadian Space Agency. The PEARL-GBS and MMCR data are available from CANDAC (http://www.candac.ca). The ozonesonde and radiosonde data for this paper are available through the Canadian Arctic ACE Validation Campaigns http://acebox.uwaterloo.ca/eureka/Eureka2011/). Any additional data may be obtained from Xiaoyi Zhao (email: [email protected]). X. Zhao is partially supported by the NSERC CREATE Training Programin Arctic Atmospheric Science. R. Schofield received funding support for this work from the Australian Research Councils Centre of Excellence (CE110001028) scheme. Ozonesonde, radiosonde, and MMCR measurements were provided by David Tarasick, David Hudak, and Peter Rodriguez at Environment Canada. The QDOAS software and AMFs were provided by C. Fayt, F. Hendrick, and M. Van Roozendael at IASB-BIRA. Many thanks to Alexei Rozanov from IUP Bremen for providing the SCIATRAN radiative transfer model. We also want to thank Paul Telford and John Pyle at the University of Cambridge for supporting the UM-UKCA model integration. We thank the NSIDC, University of Colorado, the NOAA Air Resources Laboratory, and the ECMWF for providing data sets andmodels. NCEP Reanalysis data were provided by the NOAA/OAR/ESRL PSD, Boulder, Colorado.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1983
Y1 - 1983
N2 - Measurement of pancreatic (P) and salivary-like (S) amylase isoenzyme activity in serum of adults is useful as an indirect indicator of pancreatic and salivary gland exocrine dysfunction. To extend the use of this assay to the pediatric population, we measured amylase isoenzymes in 546 serum and plasma samples and defined normal reference intervals for the P and S isoenzymes as a function of age in newborns, infants, and children. The mean activity of P isoenzyme in newborns is 3% of that of adults, begins to increase at seven to eight months, and reaches adult values by five years. The mean activity of S isoenzyme in serum is 32% of the adult mean at birth, begins to increase by three to four months, and reaches adult values by 19 months; children five to 12 years old have slightly higher values than adults. These changes with age underscore the importance of the use of age-matched reference intervals when serum amylase isoenzyme activities are measured as diagnostic indicators.
AB - Measurement of pancreatic (P) and salivary-like (S) amylase isoenzyme activity in serum of adults is useful as an indirect indicator of pancreatic and salivary gland exocrine dysfunction. To extend the use of this assay to the pediatric population, we measured amylase isoenzymes in 546 serum and plasma samples and defined normal reference intervals for the P and S isoenzymes as a function of age in newborns, infants, and children. The mean activity of P isoenzyme in newborns is 3% of that of adults, begins to increase at seven to eight months, and reaches adult values by five years. The mean activity of S isoenzyme in serum is 32% of the adult mean at birth, begins to increase by three to four months, and reaches adult values by 19 months; children five to 12 years old have slightly higher values than adults. These changes with age underscore the importance of the use of age-matched reference intervals when serum amylase isoenzyme activities are measured as diagnostic indicators.
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U2 - 10.1093/clinchem/29.6.1119
DO - 10.1093/clinchem/29.6.1119
M3 - Article
C2 - 6189641
AN - SCOPUS:0020641553
SN - 0009-9147
VL - 29
SP - 1119
EP - 1123
JO - Clinical Chemistry
JF - Clinical Chemistry
IS - 6
ER -