Reengineering Critical Laboratory Testing for Timely Chemotherapeutic Management

Xin Yi, Edward Ki Yun Leung, Diane Mika, Rebecca J. Wolsky, Charles Van Slambrouck, Julie Leanse, Chadi Nabhan, Kiang Teck J. Yeo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


BACKGROUND: Delivery of cytotoxic therapy is a complex multifaceted process that involves harmonized collaboration between all systems involved. Optimizing laboratory turnaround time (TAT) ensures timely delivery of chemotherapy, which potentially translates into improved patient outcomes and satisfaction. In this study, we aimed to reduce the laboratory TAT for key laboratory tests to optimize the timely administration of chemotherapy. METHODS: TAT data for complete blood count (CBC) and comprehensive metabolic panel (CMP) included specimen collection to receipt (Col-Rcv), specimen receipt to result release (Rcv-Res), and the overall TAT from specimen collection to result release (Col-Res). Work flows were reconfigured to transport CBC specimens directly to the hematology laboratory after collection and to treat all CMP samples from chemotherapy clinics as urgent [i.e., shortest turnaround time (STAT)]. From the CMP, total bilirubin and creatinine-the 2 key analytes for liver and renal toxicity assessment before chemotherapy drug administration-were analyzed on ABL 800 whole blood analyzers to further improve the laboratory TAT. RESULTS: CBC showed a significant reduction in the median (Col-Res) TAT to 16 min (P < 0.0001). For CMP, by processing all specimens as STAT samples, the median (Col-Res) TAT was reduced from 74 min to 54 min (P < 0.0001), and it was further reduced to 9 min (P < 0.0001) for total bilirubin and creatinine. CONCLUSION: Careful work flow analysis and reengineering of preanalytical and analytical process for key laboratory tests significantly reduced median overall TAT to <20 min, which helped facilitate more timely delivery of chemotherapy, without necessitating the construction of a satellite laboratory.

Original languageEnglish (US)
Pages (from-to)240-249
Number of pages10
JournalThe journal of applied laboratory medicine
Issue number2
StatePublished - Sep 1 2018

ASJC Scopus subject areas

  • Medicine(all)


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