Reduction of naturally occurring motoneuron death in vivo by a target-derived neurotrophic factor

Ronald W. Oppenheim, Lanny J. Haverkamp, David Prevette, James L. McManaman, Stanley H. Appel

Research output: Contribution to journalArticle

191 Scopus citations

Abstract

Treatment of chick embryos in ovo with crude and partially purified extracts from embryonic hindlimbs (days 8 to 9) during the normal cell death period (days 5 to 10) rescues a significant number of motoneurons from degeneration. The survival activity of partially purified extract was dose-dependent and developmentally regulated. The survival of sensory, sympathetic, parasympathetic, and a population of cholinergic sympathetic preganglionic neurons was unaffected by treatment with hindlimb extract. The massive motoneuron death that occurs after early target (hindlimb) removal was partially ameliorated by daily treatment with the hindlimb extract. These results indicate that a target-derived neurotrophic factor is involved in the regulation of motoneuron survival in vivo.

Original languageEnglish (US)
Pages (from-to)919-922
Number of pages4
JournalScience
Volume240
Issue number4854
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • General

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