Redifferentiation of human hepatoma cells (SMMC-7721) induced by two new highly oxygenated bisabolane-type sesquiterpenes

Ruidong Miao, Juan Wei, Qi Zhang, Venkateswara Sajja, Jinbo Yang, Qin Wang

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Bisabolane-type sesquiterpenes are a class of biologically active compounds that has antitumour, antifungal, antibacterial, antioxidant and antivenom properties. We investigated the effect of two new highly oxygenated bisabolane-type sesquiterpenes (HOBS) isolated from Cremanthodium discoideum (C. discoideum) on tumour cells. Our results showed that HOBS induced morphological differentiation and reduced microvilli formation on the cell surface in SMMC-7721 cells. Flow cytometry analysis demonstrated that HOBS could induce cell-cycle arrest in the G1 phase. Moreover, HOBS was able to increase tyrosine-α-ketoglutarate transaminase activity, decrease α foetoprotein level and γ-glutamyl transferase activity. In addition, we found that HOBS inhibited the anchorageindependent growth of SMMC-7721 cells in a dose-dependent manner. Taken together, all the above observations indicate that HOBS might be able to normalize malignant SMMC-7721 cells by inhibiting cell proliferation and inducing redifferentiation.

Original languageEnglish (US)
Pages (from-to)723-730
Number of pages8
JournalJournal of Biosciences
Volume33
Issue number5
DOIs
StatePublished - Dec 2008

Keywords

  • Oxygenated bisabolane-type sesquiterpenes (HOBS)
  • Proliferation
  • Redifferentiation
  • Tumour

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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