TY - JOUR
T1 - Redefining medical treatment in the management of unstable angina
AU - Braunwald, Eugene
AU - Califf, Robert M.
AU - Cannon, Christopher P.
AU - Fox, Keith A.A.
AU - Fuster, Valentin
AU - Gibler, W. Brian
AU - Harrington, Richard A.
AU - King, Spencer B.
AU - Kleiman, Neil S.
AU - Theroux, Pierre
AU - Topol, Eric J.
AU - Van De Werf, Frans
AU - White, Harvey D.
AU - Willerson, James T.
PY - 2000/1
Y1 - 2000/1
N2 - In 1994, the Agency for Health Care Policy and Research sponsored the development of guidelines for diagnosing and managing patients with unstable angina. Since their publication, several important developments have occurred. The prognostic value of biochemical assays for cardiac-specific troponins T and I have been shown in many studies. The possible role for C-reactive protein in determining prognosis deserves further investigation. Substantial clinical benefits have been obtained with intravenous inhibitors of the platelet glycoprotein (GP) IIb-IIIa receptor (abciximab, eptifibatide, tirofiban) and with one of the low-molecular-weight heparins (enoxaparin). The therapeutic potential of other low-molecular-weight heparins, direct thrombin inhibitors, and oral GP IIb-IIIa inhibitors remains to be clarified. On the basis of this evidence, consideration should be given to measuring serum levels of a cardiac troponin (either T or I) and using intravenous GP IIb-IIIa inhibitors and low-molecular-weight heparin in the standard management of patients with unstable angina. Copyright (C) 2000 Excerpta Medica Inc.
AB - In 1994, the Agency for Health Care Policy and Research sponsored the development of guidelines for diagnosing and managing patients with unstable angina. Since their publication, several important developments have occurred. The prognostic value of biochemical assays for cardiac-specific troponins T and I have been shown in many studies. The possible role for C-reactive protein in determining prognosis deserves further investigation. Substantial clinical benefits have been obtained with intravenous inhibitors of the platelet glycoprotein (GP) IIb-IIIa receptor (abciximab, eptifibatide, tirofiban) and with one of the low-molecular-weight heparins (enoxaparin). The therapeutic potential of other low-molecular-weight heparins, direct thrombin inhibitors, and oral GP IIb-IIIa inhibitors remains to be clarified. On the basis of this evidence, consideration should be given to measuring serum levels of a cardiac troponin (either T or I) and using intravenous GP IIb-IIIa inhibitors and low-molecular-weight heparin in the standard management of patients with unstable angina. Copyright (C) 2000 Excerpta Medica Inc.
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U2 - 10.1016/S0002-9343(99)00416-7
DO - 10.1016/S0002-9343(99)00416-7
M3 - Review article
C2 - 11059440
AN - SCOPUS:0033977734
VL - 108
SP - 41
EP - 53
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 1
ER -