Recurrent tumefactive demyelinating lesions in an elderly woman

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Here we describe a 72-year old Caucasian woman who presented with progressive left hemiparesis and hemisensory deficits due to a pathology-confirmed tumefactive demyelinating lesion in the right frontoparietal region. Symptoms improved with glucocorticoids and plasmapheresis, but five months following initial presentation, the patient developed right visual field deficits and acute encephalopathy. Brain imaging revealed near resolution of the initial lesion with interval development of new multifocal tumefactive demyelinating lesions. This case highlights several atypical features associated with tumefactive demyelinating disease, including an older age of onset and recurrent, treatment-resistant lesions. Clinical and neuroimaging features which may be helpful in diagnosing this rare disorder are reviewed.

Original languageEnglish (US)
Pages (from-to)4570-4574
Number of pages5
JournalRadiology Case Reports
Issue number12
StatePublished - Dec 2022


  • Neuroimaging
  • Tumefactive demyelination

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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