Recurrent subependymoma of fourth ventricle with unusual atypical histological features: A case report

Nishant Tiwari, Suzanne Zein-Eldin Powell, Hidehiro Takei

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Subependymoma is a rare subtype of benign ependymal neoplasm with distinct histological features. Anaplastic transformation has not yet been reported in this tumor to date. We present here a very unusual case of a 62-year-old woman with recurrent subependymoma of the fourth ventricle with multiple atypical histological features. Histologically, the resected recurrent tumor showed characteristic small cell clusters and nests of ependymal cells with an interspersed gliofibrillary matrix as seen in a classic subependymoma. In addition, there were very unusual histological features, including multiple areas of necrosis, microvascular proliferation, thrombosed blood vessels, and scattered mitotic figures. No coexisting ependymoma component of higher World Health Organization (WHO) grade was present. Immunohistochemically, MIB-1 labeling index was high, with up to 15% in the highest areas. Review of this patient's initial tumor, which was resected 6 years prior to recurrence, demonstrated features of a typical classic subependymoma without atypical features or a secondary tumor component. Subependymomas are known to be low-grade tumors and are usually cured if completely excised. The tumor presented here is unique in that several atypical pathological features were found in an otherwise typical subependymoma. Our case may represent anaplastic transformation of subependymoma, although no such examples have been reported to date.

Original languageEnglish (US)
Pages (from-to)438-442
Number of pages5
JournalPathology International
Issue number8
StatePublished - Aug 1 2015


  • Anaplastic transformation
  • Atypical pathologic features
  • Brain
  • Recurrence
  • Subependymoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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