Recovery of immurioglobulin isotypes following T‐cell depleted allogeneic bone marrow transplantation

M. K. Brenner, J. Z. Wimperis, J. E. Reittie, J. Patterson, G. L. Asherson, A. V. Hoffbrand, H. G. Prentice

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

After conventional bone marrow transplantation serum IgG, IgM and IgA levels fall from pre-transplant levels and may not return to normal for 3-12 months. In contrast IgE may rise to supranormal levels, an event that may be associated with graft-versus-host disease. We have investigated the recovery of immunoglobulin isotypes in the recipients of allogeneic marrows depleted of T-cells to prevent graft-versus-host disease. We find that pre-transplant IgG, IgM and IgA levels are maintained throughout the post-transplant period but that there is a short-lived rise in IgE about 3 weeks after transplantation: this rise occurs in the absence of clinically detectable graft-versus-host disease. We conclude that specific T-cell depletion does not impair and may actually enhance the functional recovery of B cells after allogeneic BMT.

Original languageEnglish (US)
Pages (from-to)125-132
Number of pages8
JournalBritish Journal of Haematology
Volume64
Issue number1
DOIs
StatePublished - Sep 1986

ASJC Scopus subject areas

  • Hematology

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