Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase

Andrew Parkinson; Larry W. Robertson; Stephen Safe

doi:10.1016/0006-291X(80)91438-2

Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase

Andrew Parkinson, Larry W. Robertson, Stephen Safe

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The major polychlorinated biphenyl (PCB) components identified in human breast milk have been synthesized and a reconstituted breast milk PCB mixture representing the average levels determined in the Osaka Prefecture in Japan has been prepared. The dose effecting the half-maximal (ED₅₀) induction of rat hepatic microsomal aryl hydrocarbon hydroxylase (AHH) for the reconstituted breast milk PCBs (ED₅₀ ∼12 μmol·kg⁻¹) was approximately seven times less than the ED₅₀ for the commercial PCB mixture, Kanechlor 500. The increased biological potency of the former mixture reflects the preferential bioconcentration of the toxic PCB congeners, 2,3,3′,4,4′-penta-, 2,3′,4,4′,5-penta- and 2,3,3′,4,4′,5-hexachlorobiphenyl.

Original language	English (US)
Pages (from-to)	882-889
Number of pages	8
Journal	Topics in Catalysis
Volume	96
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(80)91438-2
State	Published - 1980

Keywords

4-dimethylamino-antipyrine
AHH
B[a]P
CO
DMAP
EIC
MC
PB
PCBs
aryl hydrocarbon hydroxylase
benzo[a]pyrene hydroxylase
carbon monoxide
ethylisocyanide
methyl-cholanthrene
phenobarbitone
polychlorinated biphenyls

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Biophysics
Molecular Biology

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10.1016/0006-291X(80)91438-2

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title = "Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase",

abstract = "The major polychlorinated biphenyl (PCB) components identified in human breast milk have been synthesized and a reconstituted breast milk PCB mixture representing the average levels determined in the Osaka Prefecture in Japan has been prepared. The dose effecting the half-maximal (ED50) induction of rat hepatic microsomal aryl hydrocarbon hydroxylase (AHH) for the reconstituted breast milk PCBs (ED50 ∼12 μmol·kg−1) was approximately seven times less than the ED50 for the commercial PCB mixture, Kanechlor 500. The increased biological potency of the former mixture reflects the preferential bioconcentration of the toxic PCB congeners, 2,3,3′,4,4′-penta-, 2,3′,4,4′,5-penta- and 2,3,3′,4,4′,5-hexachlorobiphenyl.",

keywords = "4-dimethylamino-antipyrine, AHH, B[a]P, CO, DMAP, EIC, MC, PB, PCBs, aryl hydrocarbon hydroxylase, benzo[a]pyrene hydroxylase, carbon monoxide, ethylisocyanide, methyl-cholanthrene, phenobarbitone, polychlorinated biphenyls",

author = "Andrew Parkinson and Robertson, {Larry W.} and Stephen Safe",

year = "1980",

doi = "10.1016/0006-291X(80)91438-2",

language = "English (US)",

volume = "96",

pages = "882--889",

journal = "Topics in Catalysis",

publisher = "Editrice Compositori s.r.l.",

number = "2",

}

TY - JOUR

T1 - Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase

AU - Parkinson, Andrew

AU - Robertson, Larry W.

AU - Safe, Stephen

PY - 1980

Y1 - 1980

N2 - The major polychlorinated biphenyl (PCB) components identified in human breast milk have been synthesized and a reconstituted breast milk PCB mixture representing the average levels determined in the Osaka Prefecture in Japan has been prepared. The dose effecting the half-maximal (ED50) induction of rat hepatic microsomal aryl hydrocarbon hydroxylase (AHH) for the reconstituted breast milk PCBs (ED50 ∼12 μmol·kg−1) was approximately seven times less than the ED50 for the commercial PCB mixture, Kanechlor 500. The increased biological potency of the former mixture reflects the preferential bioconcentration of the toxic PCB congeners, 2,3,3′,4,4′-penta-, 2,3′,4,4′,5-penta- and 2,3,3′,4,4′,5-hexachlorobiphenyl.

AB - The major polychlorinated biphenyl (PCB) components identified in human breast milk have been synthesized and a reconstituted breast milk PCB mixture representing the average levels determined in the Osaka Prefecture in Japan has been prepared. The dose effecting the half-maximal (ED50) induction of rat hepatic microsomal aryl hydrocarbon hydroxylase (AHH) for the reconstituted breast milk PCBs (ED50 ∼12 μmol·kg−1) was approximately seven times less than the ED50 for the commercial PCB mixture, Kanechlor 500. The increased biological potency of the former mixture reflects the preferential bioconcentration of the toxic PCB congeners, 2,3,3′,4,4′-penta-, 2,3′,4,4′,5-penta- and 2,3,3′,4,4′,5-hexachlorobiphenyl.

KW - 4-dimethylamino-antipyrine

KW - AHH

KW - B[a]P

KW - CO

KW - DMAP

KW - EIC

KW - MC

KW - PB

KW - PCBs

KW - aryl hydrocarbon hydroxylase

KW - benzo[a]pyrene hydroxylase

KW - carbon monoxide

KW - ethylisocyanide

KW - methyl-cholanthrene

KW - phenobarbitone

KW - polychlorinated biphenyls

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U2 - 10.1016/0006-291X(80)91438-2

DO - 10.1016/0006-291X(80)91438-2

M3 - Article

C2 - 6775632

AN - SCOPUS:0019160167

VL - 96

SP - 882

EP - 889

JO - Topics in Catalysis

JF - Topics in Catalysis

IS - 2

ER -

Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase

Abstract

Keywords

ASJC Scopus subject areas

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