Recommendations for probiotic use--2008.

Martin H. Floch, W. Allan Walker, Stefano Guandalini, Patricia Hibberd, Sherwood Gorbach, Christina Surawicz, Mary Ellen Sanders, Guadalupe Garcia-Tsao, Eamonn M.M. Quigley, Erika Isolauri, Richard N. Fedorak, Levinus A. Dieleman

Research output: Contribution to journalReview articlepeer-review

110 Scopus citations


Recommendations for the clinical use of probiotics were published after a Yale University Workshop in 2005. A similar workshop was held in 2007, and the recommendations were updated and extended into other areas. The recommendations are graded into an "A," "B," "C" or no category based on the expert's opinion and review by the workshop participants. An "A" recommendation is made for acute childhood diarrhea, prevention of antibiotic-associated diarrhea, preventing and maintaining remission in pouchitis, and in an immune response for the treatment and prevention of atopic eczema associated with cow's milk allergy. The group maintained several "B" recommendations in other areas of treating inflammatory bowel disease and irritable bowel syndrome. Although there are significant studies in the "B" group, most "B" recommendations did not reach an "A" level because of some negative studies or a limited number of studies. Many reports in the "C" recommendations were significant but fell short of receiving stronger ratings because of the size of reported patient studies, and also the factors that limited categories to the "B" rating.

Original languageEnglish (US)
Pages (from-to)S104-108
JournalJournal of Clinical Gastroenterology
Volume42 Suppl 2
StatePublished - Jul 2008

ASJC Scopus subject areas

  • Gastroenterology


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