Recombinant proteins and genomics in cancer therapy

Kapil Mehta, Bulent Ozpolat, Kishorchandra Gohil, Bharat B. Aggarwal

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Recently published sequence of the complete human genome represents a major milestone in the era of the modern molecular biology [318, 132]. The sequencing of approximately 3.2 billion nucleotides of the human genome that is estimated to contain about 20,000-25,000 protein-encoding genes signifies the first step down the long road. Gene identification does not necessarily translate into an understanding of gene function. Although mapping and cloning of several genes have linked them to heritable genetic disorders, the normal function of a majority of these genes remains unknown. Recombinant DNA technology has made it possible to generate large amounts of many biologically active proteins and to delineate their functions. The novelty of recombinant technology is the precision and efficiency with which scientists can manipulate single gene. The ability to isolate human genes and insert them into microorganisms, which then produce human proteins, thereby serving as biological factories, has revolutionized the field of biology.

Original languageEnglish (US)
Title of host publicationPrinciples of Cancer Biotherapy
Subtitle of host publication5th Edition
PublisherSpringer Netherlands
Number of pages31
ISBN (Print)9789048122776
StatePublished - 2009

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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