Reciprocal interactions between mesenchymal stem cells and macrophages

Małgorzata Kloc; Ahmed Uosef; Monika Leśniak; Jacek Z. Kubiak; Rafik M. Ghobrial

doi:10.1387/ijdb.200242jc

Reciprocal interactions between mesenchymal stem cells and macrophages

Małgorzata Kloc, Ahmed Uosef, Monika Leśniak, Jacek Z. Kubiak, Rafik M. Ghobrial

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Mesenchymal stem cells (MSCs) are used as therapeutic agents for the treatment of a wide spectrum of diseases, as well as for the regeneration and healing of burns and wounds. MSCs have an immunomodulatory effect and influence the phenotype and functions of immune cells, including macrophages, which in turn prime and license the MSCs. We discuss the new findings on the feedback loop between MSCs and macrophages and its consequences on the outcome of MSC therapies.

Original language	English (US)
Pages (from-to)	465-469
Number of pages	5
Journal	International Journal of Developmental Biology
Volume	64
Issue number	10-11-12
DOIs	https://doi.org/10.1387/ijdb.200242jc
State	Published - 2020

Keywords

Immunomodulation
MSC
MSC therapy
Macrophage
Mesenchymal stem cell

ASJC Scopus subject areas

Embryology
Developmental Biology

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10.1387/ijdb.200242jc

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title = "Reciprocal interactions between mesenchymal stem cells and macrophages",

abstract = "Mesenchymal stem cells (MSCs) are used as therapeutic agents for the treatment of a wide spectrum of diseases, as well as for the regeneration and healing of burns and wounds. MSCs have an immunomodulatory effect and influence the phenotype and functions of immune cells, including macrophages, which in turn prime and license the MSCs. We discuss the new findings on the feedback loop between MSCs and macrophages and its consequences on the outcome of MSC therapies.",

keywords = "Immunomodulation, MSC, MSC therapy, Macrophage, Mesenchymal stem cell",

author = "Ma{\l}gorzata Kloc and Ahmed Uosef and Monika Le{\'s}niak and Kubiak, {Jacek Z.} and Ghobrial, {Rafik M.}",

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year = "2020",

doi = "10.1387/ijdb.200242jc",

language = "English (US)",

volume = "64",

pages = "465--469",

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T1 - Reciprocal interactions between mesenchymal stem cells and macrophages

AU - Kloc, Małgorzata

AU - Uosef, Ahmed

AU - Leśniak, Monika

AU - Kubiak, Jacek Z.

AU - Ghobrial, Rafik M.

PY - 2020

Y1 - 2020

N2 - Mesenchymal stem cells (MSCs) are used as therapeutic agents for the treatment of a wide spectrum of diseases, as well as for the regeneration and healing of burns and wounds. MSCs have an immunomodulatory effect and influence the phenotype and functions of immune cells, including macrophages, which in turn prime and license the MSCs. We discuss the new findings on the feedback loop between MSCs and macrophages and its consequences on the outcome of MSC therapies.

AB - Mesenchymal stem cells (MSCs) are used as therapeutic agents for the treatment of a wide spectrum of diseases, as well as for the regeneration and healing of burns and wounds. MSCs have an immunomodulatory effect and influence the phenotype and functions of immune cells, including macrophages, which in turn prime and license the MSCs. We discuss the new findings on the feedback loop between MSCs and macrophages and its consequences on the outcome of MSC therapies.

KW - Immunomodulation

KW - MSC

KW - MSC therapy

KW - Macrophage

KW - Mesenchymal stem cell

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JO - International Journal of Developmental Biology

JF - International Journal of Developmental Biology

IS - 10-11-12

ER -

Reciprocal interactions between mesenchymal stem cells and macrophages

Abstract

Keywords

ASJC Scopus subject areas

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