Receptor-mediated uptake of hypertriglyceridemic very low density lipoproteins by normal human fibroblasts

S. H. Gianturco, F. B. Brown, Antonio Gotto, W. A. Bradley

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Hypertriglyceridemic VLDL S(f) 60-400 are bound, internalized, and degraded by normal fibroblasts primarily by the high affinity LDL receptor-mediated pathway; by contrast, normal VLDL S(f) 60-400 are bound, internalized, and degraded by normal fibroblasts primarily by nonspecific, nonsaturable routes; and of the normal VLDL subclasses, only the smallest S(f) 20-60 fraction is bound and internalized via the LDL pathway.

Original languageEnglish (US)
Pages (from-to)984-993
Number of pages10
JournalJournal of lipid research
Volume23
Issue number7
StatePublished - 1982

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

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