Receptor-mediated targeting of 67Ga-deferoxamine-folate to folate- receptor-positive human KB tumor xenografts

Carla J. Mathias; Susan Wang; Philip S. Low; David J. Waters; Mark A. Green

doi:10.1016/S0969-8051(98)00076-6

Receptor-mediated targeting of ⁶⁷Ga-deferoxamine-folate to folate- receptor-positive human KB tumor xenografts

Carla J. Mathias, Susan Wang, Philip S. Low, David J. Waters, Mark A. Green

Houston Methodist

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

The radiochemical synthesis and stability of ⁶⁷Ga-deferoxamine-folate ([⁶⁷Ga]Ga-DF-Folate) were examined as a function of DF-Folate concentration. Optimal labeling occurred at DF-Folate concentrations 22.5 μg/mL. To define the possible biological significance of variations in product formulation, the biodistribution of [⁶⁷Ga]Ga-DF-Folate was examined as a function of administered deferoxamine-folate dose in an athymic mouse KB tumor model. The folate-receptor-positive KB tumors were found to concentrate the ⁶⁷Ga radiolabel in a dose-dependent fashion, consistent with saturable involvement of the folate receptor in mediating tumor accumulation of the radiopharmaceutical.

Original language	English (US)
Pages (from-to)	23-25
Number of pages	3
Journal	Nuclear Medicine and Biology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/S0969-8051(98)00076-6
State	Published - Jan 1999

Keywords

Ga-Deferoxamine-folate
Folate receptor
Tumor-targeting

ASJC Scopus subject areas

Cancer Research
Molecular Medicine
Radiology Nuclear Medicine and imaging

Access to Document

10.1016/S0969-8051(98)00076-6

Cite this

@article{95322170256143a49bd16dccc041beb7,

title = "Receptor-mediated targeting of 67Ga-deferoxamine-folate to folate- receptor-positive human KB tumor xenografts",

abstract = "The radiochemical synthesis and stability of 67Ga-deferoxamine-folate ([67Ga]Ga-DF-Folate) were examined as a function of DF-Folate concentration. Optimal labeling occurred at DF-Folate concentrations 22.5 μg/mL. To define the possible biological significance of variations in product formulation, the biodistribution of [67Ga]Ga-DF-Folate was examined as a function of administered deferoxamine-folate dose in an athymic mouse KB tumor model. The folate-receptor-positive KB tumors were found to concentrate the 67Ga radiolabel in a dose-dependent fashion, consistent with saturable involvement of the folate receptor in mediating tumor accumulation of the radiopharmaceutical.",

keywords = "Ga-Deferoxamine-folate, Folate receptor, Tumor-targeting",

author = "Mathias, {Carla J.} and Susan Wang and Low, {Philip S.} and Waters, {David J.} and Green, {Mark A.}",

note = "Funding Information: This work was supported in part by The Walther Cancer Institute, a “Jump-Start” Grant awarded by the Purdue Cancer Center, and a grant from the National Cancer Institute (RO1-CA70845).",

year = "1999",

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T1 - Receptor-mediated targeting of 67Ga-deferoxamine-folate to folate- receptor-positive human KB tumor xenografts

AU - Mathias, Carla J.

AU - Wang, Susan

AU - Low, Philip S.

AU - Waters, David J.

AU - Green, Mark A.

N1 - Funding Information: This work was supported in part by The Walther Cancer Institute, a “Jump-Start” Grant awarded by the Purdue Cancer Center, and a grant from the National Cancer Institute (RO1-CA70845).

PY - 1999/1

Y1 - 1999/1

N2 - The radiochemical synthesis and stability of 67Ga-deferoxamine-folate ([67Ga]Ga-DF-Folate) were examined as a function of DF-Folate concentration. Optimal labeling occurred at DF-Folate concentrations 22.5 μg/mL. To define the possible biological significance of variations in product formulation, the biodistribution of [67Ga]Ga-DF-Folate was examined as a function of administered deferoxamine-folate dose in an athymic mouse KB tumor model. The folate-receptor-positive KB tumors were found to concentrate the 67Ga radiolabel in a dose-dependent fashion, consistent with saturable involvement of the folate receptor in mediating tumor accumulation of the radiopharmaceutical.

AB - The radiochemical synthesis and stability of 67Ga-deferoxamine-folate ([67Ga]Ga-DF-Folate) were examined as a function of DF-Folate concentration. Optimal labeling occurred at DF-Folate concentrations 22.5 μg/mL. To define the possible biological significance of variations in product formulation, the biodistribution of [67Ga]Ga-DF-Folate was examined as a function of administered deferoxamine-folate dose in an athymic mouse KB tumor model. The folate-receptor-positive KB tumors were found to concentrate the 67Ga radiolabel in a dose-dependent fashion, consistent with saturable involvement of the folate receptor in mediating tumor accumulation of the radiopharmaceutical.

KW - Ga-Deferoxamine-folate

KW - Folate receptor

KW - Tumor-targeting

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