Recent updates on alcoholic hepatitis

Lindsey C. Shipley, Sudha Kodali, Ashwani K. Singal

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Alcoholic hepatitis (AH)is a unique clinical syndrome that affects patients with chronic and active harmful alcohol consumption, and is associated with a high mortality of up to 40% at 1 month from presentation. It is important to assess disease severity and prognosis at time of presentation to identify patients at risk for high mortality and potential candidates for specific therapies. The cornerstone therapy for AH is enteral nutrition and abstinence. Steroids remain the only pharmacological option for severe AH however, adverse effects and lack of long-term benefit limit their routine use. Early liver transplantation is a potential salvage therapy for select severe AH patients. This review article comprehensively covers recent advances on the clinical unmet needs in the field including newer therapies and therapeutic targets, role of liver transplantation, and emerging biomarkers throughout the disease process from diagnosis, assessing prognosis and disease severity, and predicting responsiveness to medical therapies for severe AH.

Original languageEnglish (US)
Pages (from-to)761-768
Number of pages8
JournalDigestive and Liver Disease
Volume51
Issue number6
DOIs
StatePublished - Jun 2019

Keywords

  • Alcoholic liver disease
  • ALD
  • Biomarkers
  • Corticosteroids
  • Liver transplantation
  • SAH

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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