Recent progress on the pro and cons of biological effects of nanomaterials

Guo Qiang Zhou, Chun Ying Chen, Yu Feng Li, Wei Li, Yu Xi Gao, Yu Liang Zhao

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


With the rapid developing of nanotechnology, the use of nanomaterials in medical imaging, disease diagnoses, drug delivery, cancer treatment, gene therapy, and basic research have also progressed quickly. The beneficial uses of nanomaterials may cause human exposure through inhalation, ingestion, skin uptake, and intravenous injection. When nanomaterials interact with biological systems, they may generate adverse biological effects. The possible toxic effects of these nanomaterials are unknown until now. The positive applications in biomedicine as well as the negative biological effects of nanomaterials on cardiovascular, respiratory and other systems are highlighted, the possible mechanisms by which nanoparticles result in cardiovascular and pulmonary morbidity are also discussed, and the possible interaction routes and sequences is farther reviewed. Finally, the perspective of risk assessment of nanomaterials in the nature is summarized.

Original languageEnglish (US)
Pages (from-to)998-1006
Number of pages9
JournalProgress in Biochemistry and Biophysics
Issue number9
StatePublished - Sep 2008


  • Biomedical application
  • Environmental health
  • Nanomaterials
  • Nanotoxicology

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics


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