TY - JOUR
T1 - Recent Progress in Non-motor Features of Parkinson’s Disease with a Focus on Circadian Rhythm Dysregulation
AU - Liu, Yufei
AU - Niu, Long
AU - Liu, Xinyao
AU - Cheng, Cheng
AU - Le, Weidong
N1 - Funding Information:
This review was supported by the National Nature Science Foundation of China (81771521), Key Research and Development Plan of Liaoning Science and Technology Department (2018225051), Guangdong Provincial Key R&D Program (2018B030337001), and the National Key Research and Development Program of China (2016YFC1306600).
Funding Information:
This review was supported by the National Nature Science Foundation of China (81771521), Key Research and Development Plan of Liaoning Science and?Technology Department (2018225051), Guangdong Provincial Key R&D Program (2018B030337001), and the National Key Research and Development Program of China (2016YFC1306600).
Publisher Copyright:
© 2021, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences.
PY - 2021/7
Y1 - 2021/7
N2 - Parkinson’s disease (PD) is the second most common neurodegenerative disease, which manifests with both motor and non-motor symptoms. Circadian rhythm dysregulation, as one of the most challenging non-motor features of PD, usually appears long before obvious motor symptoms. Moreover, the dysregulated circadian rhythm has recently been reported to play pivotal roles in PD pathogenesis, and it has emerged as a hot topic in PD research. In this review, we briefly introduce the circadian rhythm and circadian rhythm-related genes, and then summarize recent research progress on the altered circadian rhythm in PD, ranging from clinical features to the possible causes of PD-related circadian disorders. We believe that future comprehensive studies on the topic may not only help us to explore the mechanisms of PD, but also shed light on the better management of PD.
AB - Parkinson’s disease (PD) is the second most common neurodegenerative disease, which manifests with both motor and non-motor symptoms. Circadian rhythm dysregulation, as one of the most challenging non-motor features of PD, usually appears long before obvious motor symptoms. Moreover, the dysregulated circadian rhythm has recently been reported to play pivotal roles in PD pathogenesis, and it has emerged as a hot topic in PD research. In this review, we briefly introduce the circadian rhythm and circadian rhythm-related genes, and then summarize recent research progress on the altered circadian rhythm in PD, ranging from clinical features to the possible causes of PD-related circadian disorders. We believe that future comprehensive studies on the topic may not only help us to explore the mechanisms of PD, but also shed light on the better management of PD.
KW - Circadian rhythm dysregulation
KW - Circadian rhythm gene
KW - Dopamine
KW - Parkinson’s disease
KW - REM sleep behavior disorder
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U2 - 10.1007/s12264-021-00711-x
DO - 10.1007/s12264-021-00711-x
M3 - Review article
C2 - 34128188
AN - SCOPUS:85107871369
VL - 37
SP - 1010
EP - 1024
JO - Neuroscience Bulletin
JF - Neuroscience Bulletin
SN - 1673-7067
IS - 7
ER -