Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy

Mitchell S. Anscher, Liguang Chen, Zahid Rabbani, Song Kang, Nicole Larrier, Hong Huang, Thaddeus V. Samulski, Mark W. Dewhirst, David M. Brizel, Rodney J. Folz, Zeljko Vujaskovic

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

The ability to optimize treatments for cancer on the basis of relative risks for normal tissue injury has important implications in oncology, because higher doses of radiation might, in some diseases, improve both local control and survival. To achieve this goal, a thorough understanding of the molecular mechanisms responsible for radiation-induced toxicity will be essential. Recent research has demonstrated that ionizing radiation triggers a series of genetic and molecular events, which might lead to chronic persistent alterations in the microenvironment and an aberrant wound-healing response. Disrupted epithelial-stromal cell communication might also be important. With the application of a better understanding of fundamental biology to clinical practice, new approaches to treating and preventing normal tissue injury can focus on correcting these disturbed molecular processes.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalInternational Journal of Radiation Oncology Biology Physics
Volume62
Issue number1
DOIs
StatePublished - May 1 2005

Keywords

  • Complications
  • Cytokines
  • Radiation therapy
  • Treatment

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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