Recent developments in polymeric nanoparticle engineering and their applications in experimental and clinical oncology

Seyed Moghimi

Research output: Contribution to journalReview article

62 Scopus citations

Abstract

Promising results have come from attempts to direct drugs, nucleic acids and diagnostic agents to tumours by using polymeric nanoparticles. Such carriers are versatile; their encapsulation capacity, drug release profile, and biological performance vary with their chemical makeup, morphology, and size. Polymeric nanoparticles may therefore be engineered for therapeutic and diagnostic purposes in accordance with the type, developmental stage and location of the cancer as well as the required route of administration. This article examines recent developments in design and engineering of polymeric nanoparticles and related platforms to include supramolecular systems such as nanocapsules and nanoparticle-based hydrogels, and assesses their potential diagnostic and therapeutic applications in experimental and clinical oncology.

Original languageEnglish (US)
Pages (from-to)553-561
Number of pages9
JournalAnti-Cancer Agents in Medicinal Chemistry
Volume6
Issue number6
DOIs
StatePublished - Nov 1 2006

Keywords

  • Drug solubilization
  • Gene transfer and therapy
  • Macrophage
  • Multidrug resistance
  • Nanocapsules
  • Nanospheres
  • Polymeric hydrogels
  • Tumour targeting

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Pharmacology

Fingerprint Dive into the research topics of 'Recent developments in polymeric nanoparticle engineering and their applications in experimental and clinical oncology'. Together they form a unique fingerprint.

Cite this