Recent advances in the in vitro evolution of nucleic acids

Joshua A. Bittker, Kevin J. Phillips, David R. Liu

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


Molecular evolution allows chemists and biologists to generate nucleic acids with tailor-made binding or catalytic activities. Recent examples of nucleic acid evolution in vitro provide insights into natural ribozyme evolution and also demonstrate potential applications of evolved DNA and RNA molecules. Efforts to expand the scope of nucleic acid evolution are also underway, including the development of novel methods for exploring nucleic acid sequence-space and the incorporation of non-natural chemical functionality into nucleic acid libraries.

Original languageEnglish (US)
Pages (from-to)367-374
Number of pages8
JournalCurrent Opinion in Chemical Biology
Issue number3
StatePublished - Jun 1 2002

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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