Real-time co-registration using novel ultrasound technology: Ex vivo validation and in vivo applications

Research output: Contribution to journalArticle

Eric Y. Yang, Venkateshwar R. Polsani, Michael J. Washburn, William Zang, Anne L. Hall, Salim S. Virani, Megan D. Hodge, Dan Parker, William S. Kerwin, Gerald M. Lawrie, Zsolt Garami, Christie M. Ballantyne, Joel D. Morrisett, Vijay Nambi

Objective: The study objective was to evaluate whether a novel global position system (GPS)-like position-sensing technology will enable accurate co-registration of images between imaging modalities. Co-registration of images obtained by different imaging modalities will allow for comparison and fusion between imaging modalities, and therefore has significant clinical and research implications. We compared ultrasound (US) and magnetic resonance imaging (MRI) scans of carotid endarterectomy (CEA) specimens using a novel position-sensing technology that uses an electromagnetic (EM) transmitter and sensors mounted on a US transducer. We then evaluated in vivo US-US and US-MRI co-registration. Methods: Thirteen CEA specimens underwent 3.0 Tesla MRI, after which images were uploaded to a LOGIQ E9 3D (GE Healthcare, Wauwatosa, WI) US system and registered by identifying two to three common points. A similar method was used to evaluate US-MRI co-registration in patients with carotid atherosclerosis. For carotid intima-media thickness (C-IMT) measurements, 10 volunteers underwent bilateral carotid US scans co-registered to three-dimensional US maps created on the initial visit, with a repeat scan 2 days later. Results: For the CEA specimens, there was a mean of 20 (standard error [SE] 2.0) frames per MRI slice. The mean frame difference, over 33 registration markers, between MRI and US scans for readers 1 and 2 was -2.82 ± 19.32 and 2.09 ± 14.68 (mean ± 95% CI) frames, respectively. The US-MRI intraclass correlation coefficients (ICCs) for the first and second readers were 0.995 and 0.997, respectively. For patients with carotid atherosclerosis, the mean US frames per MRI slice (9 [SE 2.3]) was within range of that observed with CEA specimens. Inter-visit, intra-reader, and inter-reader reproducibility of C-IMT measurements were consistently high (side-averaged ICC >0.9). Conclusion: Accurate co-registration between US and other modalities is feasible with a GPS-like technology, which has significant clinical and research applicability.

Original languageEnglish
Pages (from-to)720-728
Number of pages9
JournalJournal of the American Society of Echocardiography
Volume24
Issue number7
DOIs
StatePublished - Jul 1 2011

PMID: 21439782

PMCID: PMC3123396

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Real-time co-registration using novel ultrasound technology : Ex vivo validation and in vivo applications. / Yang, Eric Y.; Polsani, Venkateshwar R.; Washburn, Michael J.; Zang, William; Hall, Anne L.; Virani, Salim S.; Hodge, Megan D.; Parker, Dan; Kerwin, William S.; Lawrie, Gerald M.; Garami, Zsolt; Ballantyne, Christie M.; Morrisett, Joel D.; Nambi, Vijay.

In: Journal of the American Society of Echocardiography, Vol. 24, No. 7, 01.07.2011, p. 720-728.

Research output: Contribution to journalArticle

Harvard

Yang, EY, Polsani, VR, Washburn, MJ, Zang, W, Hall, AL, Virani, SS, Hodge, MD, Parker, D, Kerwin, WS, Lawrie, GM, Garami, Z, Ballantyne, CM, Morrisett, JD & Nambi, V 2011, 'Real-time co-registration using novel ultrasound technology: Ex vivo validation and in vivo applications' Journal of the American Society of Echocardiography, vol. 24, no. 7, pp. 720-728. https://doi.org/10.1016/j.echo.2011.02.003

APA

Yang, E. Y., Polsani, V. R., Washburn, M. J., Zang, W., Hall, A. L., Virani, S. S., ... Nambi, V. (2011). Real-time co-registration using novel ultrasound technology: Ex vivo validation and in vivo applications. Journal of the American Society of Echocardiography, 24(7), 720-728. https://doi.org/10.1016/j.echo.2011.02.003

Vancouver

Yang EY, Polsani VR, Washburn MJ, Zang W, Hall AL, Virani SS et al. Real-time co-registration using novel ultrasound technology: Ex vivo validation and in vivo applications. Journal of the American Society of Echocardiography. 2011 Jul 1;24(7):720-728. https://doi.org/10.1016/j.echo.2011.02.003

Author

Yang, Eric Y. ; Polsani, Venkateshwar R. ; Washburn, Michael J. ; Zang, William ; Hall, Anne L. ; Virani, Salim S. ; Hodge, Megan D. ; Parker, Dan ; Kerwin, William S. ; Lawrie, Gerald M. ; Garami, Zsolt ; Ballantyne, Christie M. ; Morrisett, Joel D. ; Nambi, Vijay. / Real-time co-registration using novel ultrasound technology : Ex vivo validation and in vivo applications. In: Journal of the American Society of Echocardiography. 2011 ; Vol. 24, No. 7. pp. 720-728.

BibTeX

@article{34b388412af946e3ba31e0cf775d0356,
title = "Real-time co-registration using novel ultrasound technology: Ex vivo validation and in vivo applications",
abstract = "Objective: The study objective was to evaluate whether a novel global position system (GPS)-like position-sensing technology will enable accurate co-registration of images between imaging modalities. Co-registration of images obtained by different imaging modalities will allow for comparison and fusion between imaging modalities, and therefore has significant clinical and research implications. We compared ultrasound (US) and magnetic resonance imaging (MRI) scans of carotid endarterectomy (CEA) specimens using a novel position-sensing technology that uses an electromagnetic (EM) transmitter and sensors mounted on a US transducer. We then evaluated in vivo US-US and US-MRI co-registration. Methods: Thirteen CEA specimens underwent 3.0 Tesla MRI, after which images were uploaded to a LOGIQ E9 3D (GE Healthcare, Wauwatosa, WI) US system and registered by identifying two to three common points. A similar method was used to evaluate US-MRI co-registration in patients with carotid atherosclerosis. For carotid intima-media thickness (C-IMT) measurements, 10 volunteers underwent bilateral carotid US scans co-registered to three-dimensional US maps created on the initial visit, with a repeat scan 2 days later. Results: For the CEA specimens, there was a mean of 20 (standard error [SE] 2.0) frames per MRI slice. The mean frame difference, over 33 registration markers, between MRI and US scans for readers 1 and 2 was -2.82 ± 19.32 and 2.09 ± 14.68 (mean ± 95{\%} CI) frames, respectively. The US-MRI intraclass correlation coefficients (ICCs) for the first and second readers were 0.995 and 0.997, respectively. For patients with carotid atherosclerosis, the mean US frames per MRI slice (9 [SE 2.3]) was within range of that observed with CEA specimens. Inter-visit, intra-reader, and inter-reader reproducibility of C-IMT measurements were consistently high (side-averaged ICC >0.9). Conclusion: Accurate co-registration between US and other modalities is feasible with a GPS-like technology, which has significant clinical and research applicability.",
keywords = "Carotid plaques, Co-registration, Magnetic resonance imaging, Plaque tissue, Ultrasound",
author = "Yang, {Eric Y.} and Polsani, {Venkateshwar R.} and Washburn, {Michael J.} and William Zang and Hall, {Anne L.} and Virani, {Salim S.} and Hodge, {Megan D.} and Dan Parker and Kerwin, {William S.} and Lawrie, {Gerald M.} and Zsolt Garami and Ballantyne, {Christie M.} and Morrisett, {Joel D.} and Vijay Nambi",
year = "2011",
month = "7",
day = "1",
doi = "10.1016/j.echo.2011.02.003",
language = "English",
volume = "24",
pages = "720--728",
journal = "Journal of the American Society of Echocardiography",
issn = "0894-7317",
publisher = "Mosby Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - Real-time co-registration using novel ultrasound technology

T2 - Journal of the American Society of Echocardiography

AU - Yang, Eric Y.

AU - Polsani, Venkateshwar R.

AU - Washburn, Michael J.

AU - Zang, William

AU - Hall, Anne L.

AU - Virani, Salim S.

AU - Hodge, Megan D.

AU - Parker, Dan

AU - Kerwin, William S.

AU - Lawrie, Gerald M.

AU - Garami, Zsolt

AU - Ballantyne, Christie M.

AU - Morrisett, Joel D.

AU - Nambi, Vijay

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Objective: The study objective was to evaluate whether a novel global position system (GPS)-like position-sensing technology will enable accurate co-registration of images between imaging modalities. Co-registration of images obtained by different imaging modalities will allow for comparison and fusion between imaging modalities, and therefore has significant clinical and research implications. We compared ultrasound (US) and magnetic resonance imaging (MRI) scans of carotid endarterectomy (CEA) specimens using a novel position-sensing technology that uses an electromagnetic (EM) transmitter and sensors mounted on a US transducer. We then evaluated in vivo US-US and US-MRI co-registration. Methods: Thirteen CEA specimens underwent 3.0 Tesla MRI, after which images were uploaded to a LOGIQ E9 3D (GE Healthcare, Wauwatosa, WI) US system and registered by identifying two to three common points. A similar method was used to evaluate US-MRI co-registration in patients with carotid atherosclerosis. For carotid intima-media thickness (C-IMT) measurements, 10 volunteers underwent bilateral carotid US scans co-registered to three-dimensional US maps created on the initial visit, with a repeat scan 2 days later. Results: For the CEA specimens, there was a mean of 20 (standard error [SE] 2.0) frames per MRI slice. The mean frame difference, over 33 registration markers, between MRI and US scans for readers 1 and 2 was -2.82 ± 19.32 and 2.09 ± 14.68 (mean ± 95% CI) frames, respectively. The US-MRI intraclass correlation coefficients (ICCs) for the first and second readers were 0.995 and 0.997, respectively. For patients with carotid atherosclerosis, the mean US frames per MRI slice (9 [SE 2.3]) was within range of that observed with CEA specimens. Inter-visit, intra-reader, and inter-reader reproducibility of C-IMT measurements were consistently high (side-averaged ICC >0.9). Conclusion: Accurate co-registration between US and other modalities is feasible with a GPS-like technology, which has significant clinical and research applicability.

AB - Objective: The study objective was to evaluate whether a novel global position system (GPS)-like position-sensing technology will enable accurate co-registration of images between imaging modalities. Co-registration of images obtained by different imaging modalities will allow for comparison and fusion between imaging modalities, and therefore has significant clinical and research implications. We compared ultrasound (US) and magnetic resonance imaging (MRI) scans of carotid endarterectomy (CEA) specimens using a novel position-sensing technology that uses an electromagnetic (EM) transmitter and sensors mounted on a US transducer. We then evaluated in vivo US-US and US-MRI co-registration. Methods: Thirteen CEA specimens underwent 3.0 Tesla MRI, after which images were uploaded to a LOGIQ E9 3D (GE Healthcare, Wauwatosa, WI) US system and registered by identifying two to three common points. A similar method was used to evaluate US-MRI co-registration in patients with carotid atherosclerosis. For carotid intima-media thickness (C-IMT) measurements, 10 volunteers underwent bilateral carotid US scans co-registered to three-dimensional US maps created on the initial visit, with a repeat scan 2 days later. Results: For the CEA specimens, there was a mean of 20 (standard error [SE] 2.0) frames per MRI slice. The mean frame difference, over 33 registration markers, between MRI and US scans for readers 1 and 2 was -2.82 ± 19.32 and 2.09 ± 14.68 (mean ± 95% CI) frames, respectively. The US-MRI intraclass correlation coefficients (ICCs) for the first and second readers were 0.995 and 0.997, respectively. For patients with carotid atherosclerosis, the mean US frames per MRI slice (9 [SE 2.3]) was within range of that observed with CEA specimens. Inter-visit, intra-reader, and inter-reader reproducibility of C-IMT measurements were consistently high (side-averaged ICC >0.9). Conclusion: Accurate co-registration between US and other modalities is feasible with a GPS-like technology, which has significant clinical and research applicability.

KW - Carotid plaques

KW - Co-registration

KW - Magnetic resonance imaging

KW - Plaque tissue

KW - Ultrasound

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U2 - 10.1016/j.echo.2011.02.003

DO - 10.1016/j.echo.2011.02.003

M3 - Article

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EP - 728

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

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