Real-world evidence to advance knowledge in pulmonary hypertension: Status, challenges, and opportunities. A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative's Real-world Evidence Working Group

Kellie Morland; Christian Gerges; Jean Elwing; Scott H. Visovatti; Jason Weatherald; Kari R. Gillmeyer; Sandeep Sahay; Stephen C. Mathai; Athénaïs Boucly; Paul G. Williams; Sivadasanpillai Harikrishnan; Evan P. Minty; Lukas Hobohm; Arun Jose; Roberto Badagliacca; Edmund M.T. Lau; Zhi Cheng Jing; Rebecca R. Vanderpool; Charles Fauvel; Jose Leonidas Alves; Geoff Strange; Tomas Pulido; Junyan Qian; Mengtao Li; Valentina Mercurio; Jason G.E. Zelt; Victor M. Moles; Meghan M. Cirulis; Sylvia M. Nikkho; Raymond L. Benza; C. Gregory Elliott

doi:10.1002/pul2.12317

Real-world evidence to advance knowledge in pulmonary hypertension: Status, challenges, and opportunities. A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative's Real-world Evidence Working Group

Kellie Morland, Christian Gerges, Jean Elwing, Scott H. Visovatti, Jason Weatherald, Kari R. Gillmeyer, Sandeep Sahay, Stephen C. Mathai, Athénaïs Boucly, Paul G. Williams, Sivadasanpillai Harikrishnan, Evan P. Minty, Lukas Hobohm, Arun Jose, Roberto Badagliacca, Edmund M.T. Lau, Zhi Cheng Jing, Rebecca R. Vanderpool, Charles Fauvel, Jose Leonidas AlvesGeoff Strange, Tomas Pulido, Junyan Qian, Mengtao Li, Valentina Mercurio, Jason G.E. Zelt, Victor M. Moles, Meghan M. Cirulis, Sylvia M. Nikkho, Raymond L. Benza, C. Gregory Elliott

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This manuscript on real-world evidence (RWE) in pulmonary hypertension (PH) incorporates the broad experience of members of the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative Real-World Evidence Working Group. We aim to strengthen the research community's understanding of RWE in PH to facilitate clinical research advances and ultimately improve patient care. Herein, we review real-world data (RWD) sources, discuss challenges and opportunities when using RWD sources to study PH populations, and identify resources needed to support the generation of meaningful RWE for the global PH community.

Original language	English (US)
Article number	e12317
Pages (from-to)	e12317
Journal	Pulmonary Circulation
Volume	13
Issue number	4
DOIs	https://doi.org/10.1002/pul2.12317 https://doi.org/10.1002/pul2.12317
State	Published - Oct 2023

Keywords

administrative claims data
electronic health records
patient-generated health data
real-world data
registries

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

Divisions

Pulmonary, Critical Care and Sleep Medicine

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Morland, K., Gerges, C., Elwing, J., Visovatti, S. H., Weatherald, J., Gillmeyer, K. R., Sahay, S., Mathai, S. C., Boucly, A., Williams, P. G., Harikrishnan, S., Minty, E. P., Hobohm, L., Jose, A., Badagliacca, R., Lau, E. M. T., Jing, Z. C., Vanderpool, R. R., Fauvel, C., ... Elliott, C. G. (2023). Real-world evidence to advance knowledge in pulmonary hypertension: Status, challenges, and opportunities. A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative's Real-world Evidence Working Group. Pulmonary Circulation, 13(4), e12317. Article e12317. https://doi.org/10.1002/pul2.12317, https://doi.org/10.1002/pul2.12317

Real-world evidence to advance knowledge in pulmonary hypertension: Status, challenges, and opportunities. A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative's Real-world Evidence Working Group. / Morland, Kellie; Gerges, Christian; Elwing, Jean et al.
In: Pulmonary Circulation, Vol. 13, No. 4, e12317, 10.2023, p. e12317.

Research output: Contribution to journal › Article › peer-review

Morland, K, Gerges, C, Elwing, J, Visovatti, SH, Weatherald, J, Gillmeyer, KR, Sahay, S, Mathai, SC, Boucly, A, Williams, PG, Harikrishnan, S, Minty, EP, Hobohm, L, Jose, A, Badagliacca, R, Lau, EMT, Jing, ZC, Vanderpool, RR, Fauvel, C, Leonidas Alves, J, Strange, G, Pulido, T, Qian, J, Li, M, Mercurio, V, Zelt, JGE, Moles, VM, Cirulis, MM, Nikkho, SM, Benza, RL & Elliott, CG 2023, 'Real-world evidence to advance knowledge in pulmonary hypertension: Status, challenges, and opportunities. A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative's Real-world Evidence Working Group', Pulmonary Circulation, vol. 13, no. 4, e12317, pp. e12317. https://doi.org/10.1002/pul2.12317, https://doi.org/10.1002/pul2.12317

Morland K, Gerges C, Elwing J, Visovatti SH, Weatherald J, Gillmeyer KR et al. Real-world evidence to advance knowledge in pulmonary hypertension: Status, challenges, and opportunities. A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative's Real-world Evidence Working Group. Pulmonary Circulation. 2023 Oct;13(4):e12317. e12317. doi: 10.1002/pul2.12317, 10.1002/pul2.12317

Morland, Kellie ; Gerges, Christian ; Elwing, Jean et al. / Real-world evidence to advance knowledge in pulmonary hypertension : Status, challenges, and opportunities. A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative's Real-world Evidence Working Group. In: Pulmonary Circulation. 2023 ; Vol. 13, No. 4. pp. e12317.

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abstract = "This manuscript on real-world evidence (RWE) in pulmonary hypertension (PH) incorporates the broad experience of members of the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative Real-World Evidence Working Group. We aim to strengthen the research community's understanding of RWE in PH to facilitate clinical research advances and ultimately improve patient care. Herein, we review real-world data (RWD) sources, discuss challenges and opportunities when using RWD sources to study PH populations, and identify resources needed to support the generation of meaningful RWE for the global PH community.",

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author = "Kellie Morland and Christian Gerges and Jean Elwing and Visovatti, \{Scott H.\} and Jason Weatherald and Gillmeyer, \{Kari R.\} and Sandeep Sahay and Mathai, \{Stephen C.\} and Ath{\'e}na{\"i}s Boucly and Williams, \{Paul G.\} and Sivadasanpillai Harikrishnan and Minty, \{Evan P.\} and Lukas Hobohm and Arun Jose and Roberto Badagliacca and Lau, \{Edmund M.T.\} and Jing, \{Zhi Cheng\} and Vanderpool, \{Rebecca R.\} and Charles Fauvel and \{Leonidas Alves\}, Jose and Geoff Strange and Tomas Pulido and Junyan Qian and Mengtao Li and Valentina Mercurio and Zelt, \{Jason G.E.\} and Moles, \{Victor M.\} and Cirulis, \{Meghan M.\} and Nikkho, \{Sylvia M.\} and Benza, \{Raymond L.\} and Elliott, \{C. Gregory\}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Pulmonary Circulation published by John Wiley \& Sons Ltd on behalf of Pulmonary Vascular Research Institute.",

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AU - Elwing, Jean

AU - Visovatti, Scott H.

AU - Weatherald, Jason

AU - Gillmeyer, Kari R.

AU - Sahay, Sandeep

AU - Mathai, Stephen C.

AU - Boucly, Athénaïs

AU - Williams, Paul G.

AU - Harikrishnan, Sivadasanpillai

AU - Minty, Evan P.

AU - Hobohm, Lukas

AU - Jose, Arun

AU - Badagliacca, Roberto

AU - Lau, Edmund M.T.

AU - Jing, Zhi Cheng

AU - Vanderpool, Rebecca R.

AU - Fauvel, Charles

AU - Leonidas Alves, Jose

AU - Strange, Geoff

AU - Pulido, Tomas

AU - Qian, Junyan

AU - Li, Mengtao

AU - Mercurio, Valentina

AU - Zelt, Jason G.E.

AU - Moles, Victor M.

AU - Cirulis, Meghan M.

AU - Nikkho, Sylvia M.

AU - Benza, Raymond L.

AU - Elliott, C. Gregory

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Real-world evidence to advance knowledge in pulmonary hypertension: Status, challenges, and opportunities. A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative's Real-world Evidence Working Group

Abstract

Keywords

ASJC Scopus subject areas

Divisions

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