Real-time tagless monitoring of cell viability using patch-clamp microdevices

Pushparaj Pathak, Hong Zhao, Zhongcheng Gong, Fang Nie, Tianhua Zhang, Stephen Wong, Long Que

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Real-time tagless monitoring of cell viability using patch-clamp microdevices is reported and validated by using fluorescence imaging techniques for the first time. Specifically, human breast cancer cells MDA-MB-231 have been used for these studies. Systematic experiments on these cells found that the impedance change of captured cells by the micro-electrodes is a valid indicator of cell's living or death, which might provide an efficient way to monitor the drug effects on cells, thereby benefiting high throughput drug screen and discovery process.

Original languageEnglish (US)
Title of host publicationIEEE Sensors 2010 Conference, SENSORS 2010
Pages2482-2485
Number of pages4
DOIs
StatePublished - 2010
Event9th IEEE Sensors Conference 2010, SENSORS 2010 - Waikoloa, HI, United States
Duration: Nov 1 2010Nov 4 2010

Publication series

NameProceedings of IEEE Sensors

Other

Other9th IEEE Sensors Conference 2010, SENSORS 2010
CountryUnited States
CityWaikoloa, HI
Period11/1/1011/4/10

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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