Reactive oxygen species and colorectal cancer

Sandeep Sreevalsan, Stephen Safe

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Several agents used for treatment of colon and other cancers induce reactive oxygen species (ROS), and this plays an important role in their anticancer activities. In addition to the well-known proapoptotic effects of ROS inducers, these compounds also decrease expression of specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 and several prooncogenic Sp-regulated genes important for cancer cell proliferation, survival, and metastasis. The mechanism of these responses involves ROS-dependent downregulation of miR-27a or miR-20a (and paralogs) and induction of two Sp repressors, ZBTB10 and ZBTB4, respectively. This pathway significantly contributes to the anticancer activity of ROS inducers and should be considered in the development of drug combinations for cancer chemotherapy.

Original languageEnglish (US)
Pages (from-to)350-357
Number of pages8
JournalCurrent Colorectal Cancer Reports
Volume9
Issue number4
DOIs
StatePublished - Dec 2013

Keywords

  • Antioxidants
  • Colon cancer
  • Mechanism-based drugs
  • MicroRNA
  • Reactive oxygen species
  • Specificity transcription factors
  • Targeted therapy
  • Zinc fingerDNA binding proteins

ASJC Scopus subject areas

  • Hepatology
  • Oncology
  • Gastroenterology

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