Rationale and Design of the CREDENCE Trial: Computed TomogRaphic evaluation of atherosclerotic DEtermiNants of myocardial IsChEmia

Asim Rizvi, Bríain Hartaigh, Paul Knaapen, Jonathon Leipsic, Leslee J. Shaw, Daniele Andreini, Gianluca Pontone, Subha Raman, Muhammad Akram Khan, Michael Ridner, Faisal Nabi, Alessia Gimelli, James Jang, Jason Cole, Ryo Nakazato, Christopher Zarins, Donghee Han, Ji Hyun Lee, Jackie Szymonifika, Millie J. GomezQuynh A. Truong, Hyuk Jae Chang, Fay Y. Lin, James K. Min

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Background: Coronary computed tomography angiography (CCTA) allows for non-invasive assessment of obstructive coronary artery disease (CAD) beyond measures of stenosis severity alone. This assessment includes atherosclerotic plaque characteristics (APCs) and calculation of fractional flow reserve (FFR) from CCTA (FFRCT). Similarly, stress imaging by myocardial perfusion scintigraphy (MPS) provides vital information. To date, the diagnostic performance of integrated CCTA assessment versus integrated MPS assessment for diagnosis of vessel-specific ischemia remains underexplored. Methods: CREDENCE will enroll adult individuals with symptoms suspicious of CAD referred for non-emergent invasive coronary angiography (ICA), but without known CAD. All participants will undergo CCTA, MPS, ICA and FFR. FFR will be performed for lesions identified at the time of ICA to be ≥40 and CT metric by CCTA for vessel-specific ischemia will be developed from derivation cohort and tested against a validation cohort. Similarly, integrated metric by MPS for vessel-specific ischemia will be developed, validated and compared. An FFR value of ≤0.80 will be considered as ischemia causing. The primary endpoint will be the diagnostic accuracy of vessel territory-specific ischemia of integrated stenosis-APC-FFRCT measure by CCTA, compared with perfusion or perfusion-myocardial blood flow stress imaging testing, against invasive FFR. Discussion: CREDENCE will determine the performance of integrated CCTA metric compared to integrated MPS measure for diagnosis of vessel-specific ischemia. If proven successful, this study may reduce the number of missed diagnoses and help to optimally predict ischemia-causing lesions. Trial registration: ClinicalTrials.gov, NCT02173275. Registered on June 23, 2014.

Original languageEnglish (US)
Article number190
JournalBMC Cardiovascular Disorders
Issue number1
StatePublished - Oct 6 2016


  • Coronary artery disease
  • Coronary computed tomography angiography
  • Fractional flow reserve
  • Myocardial blood flow
  • Myocardial perfusion scintigraphy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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