TY - JOUR
T1 - Rational Design of Nanomaterials for Various Radiation-Induced Diseases Prevention and Treatment
AU - Xie, Jiani
AU - Zhao, Maoru
AU - Wang, Chengyan
AU - Yong, Yuan
AU - Gu, Zhanjun
AU - Zhao, Yuliang
N1 - Funding Information:
J.X. and M.Z. contributed equally to this work. The authors hereby acknowledge the financial support from the Strategic Priority Research Program of Chinese Academy of Sciences [Grant No. XDB36000000], the National Basic Research Program of China [Grant Nos. 2016YFA2021600 and 2020YFA070079], the National Natural Science Foundation of China [Grant Nos. 51822207, 51772292, 31901005, and 52003031], Chinese Academy of Sciences Youth Innovation Promotion Association [Grant No. 2013007], and CAS Key Research Program of Frontier Sciences [Grant No. QYZDJ‐SSW‐SLH022].
Publisher Copyright:
© 2021 Wiley-VCH GmbH
PY - 2021/3/17
Y1 - 2021/3/17
N2 - Radiation treatments often unfavorably damage neighboring healthy organs and cause a series of radiation sequelae, such as radiation-induced hematopoietic system diseases, radiation-induced gastrointestinal diseases, radiation-induced lung diseases, and radiation-induced skin diseases. Recently, emerging nanomaterials have exhibited good superiority for these radiation-induced disease treatments. Given this background, the rational design principle of nanomaterials, which helps to optimize the therapeutic efficiency, has been an increasing need. Consequently, it is of great significance to perform a systematic summarization of the advances in this field, which can trigger the development of new high-performance nanoradioprotectors with drug efficiency maximization. Herein, this review highlights the advances and perspectives in the rational design of nanomaterials for preventing and treating various common radiation-induced diseases. Furthermore, the sources, clinical symptoms, and pathogenesis/injury mechanisms of these radiation-induced diseases will also be introduced. Furthermore, current challenges and directions for future efforts in this field are also discussed.
AB - Radiation treatments often unfavorably damage neighboring healthy organs and cause a series of radiation sequelae, such as radiation-induced hematopoietic system diseases, radiation-induced gastrointestinal diseases, radiation-induced lung diseases, and radiation-induced skin diseases. Recently, emerging nanomaterials have exhibited good superiority for these radiation-induced disease treatments. Given this background, the rational design principle of nanomaterials, which helps to optimize the therapeutic efficiency, has been an increasing need. Consequently, it is of great significance to perform a systematic summarization of the advances in this field, which can trigger the development of new high-performance nanoradioprotectors with drug efficiency maximization. Herein, this review highlights the advances and perspectives in the rational design of nanomaterials for preventing and treating various common radiation-induced diseases. Furthermore, the sources, clinical symptoms, and pathogenesis/injury mechanisms of these radiation-induced diseases will also be introduced. Furthermore, current challenges and directions for future efforts in this field are also discussed.
KW - clinical symptoms
KW - nanomaterials
KW - pathogenesis
KW - prevention and treatment
KW - radiation-induced diseases
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U2 - 10.1002/adhm.202001615
DO - 10.1002/adhm.202001615
M3 - Review article
C2 - 33506624
AN - SCOPUS:85099757198
SN - 2192-2640
VL - 10
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 6
M1 - 2001615
ER -