TY - JOUR
T1 - Rates of killing of methicillin-resistant Staphylococcus aureus by ceftaroline, daptomycin, and telavancin compared to that of vancomycin
AU - Marconescu, Praveena
AU - Graviss, Edward A.
AU - Musher, Daniel M.
PY - 2012/8
Y1 - 2012/8
N2 - Treatment failure of methicillin-resistant Staphylococcus aureus (MRSA) remains an important concern. In order to investigate new MRSA treatment modalities, we used standard timekill assays to determine the in vitro killing rate of 22 strains of MRSA by vancomycin, telavancin, daptomycin, and ceftaroline. Studies were carried out with 7-10-times the minimum bactericidal concentrations of each antibiotic in broth culture for 24 h, with subculture at 4, 8, and 24 h. We found that killing by ceftaroline closely paralleled that of vancomycin. Telavancin killed bacteria significantly more slowly, whereas daptomycin killed significantly more rapidly.
AB - Treatment failure of methicillin-resistant Staphylococcus aureus (MRSA) remains an important concern. In order to investigate new MRSA treatment modalities, we used standard timekill assays to determine the in vitro killing rate of 22 strains of MRSA by vancomycin, telavancin, daptomycin, and ceftaroline. Studies were carried out with 7-10-times the minimum bactericidal concentrations of each antibiotic in broth culture for 24 h, with subculture at 4, 8, and 24 h. We found that killing by ceftaroline closely paralleled that of vancomycin. Telavancin killed bacteria significantly more slowly, whereas daptomycin killed significantly more rapidly.
UR - http://www.scopus.com/inward/record.url?scp=84864053005&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864053005&partnerID=8YFLogxK
U2 - 10.3109/00365548.2012.669843
DO - 10.3109/00365548.2012.669843
M3 - Article
C2 - 22668202
AN - SCOPUS:84864053005
VL - 44
SP - 620
EP - 622
JO - Scandinavian Journal of Infectious Diseases
JF - Scandinavian Journal of Infectious Diseases
SN - 0036-5548
IS - 8
ER -