Rare Tumors of the Sellar Region

Aditya Raghunathan, Hidehiro Takei, Suzanne Z. Powell

Research output: Contribution to journalReview articlepeer-review


Context: The sellar/ parasellar region is the location for a vast array of neoplastic and nonneoplastic intracranial space-occupying lesions. While several common lesions arising in this location have been well-described in the literature, there are rare and challenging tumors that may also arise in this region. Objective: We focus this review on five rare tumors reported to arise in the sellar region, including spindle cell oncocytoma of the adenohypophysis, pituicytoma, intravascular papillary endothelial hyperplasia, epithelioid hemangioendothelioma and xanthogranuloma. We review their clinical presentation, histologic features, differential diagnosis and outcomes for these tumors. Data sources: All medical literature pertaining to these entities that was searchable on PubMed was comprehensively reviewed. Conclusions: Spindle cell oncocytoma and pituicytoma have recently been included in the 2007 edition of the World Health Organization classification of tumours of the CNS, while intravascular papillary endothelial hyperplasia, epithelioid hemangioendothelioma and xanthogranuloma have only rarely been described in this region. Knowledge of these may help prevent possible diagnostic pitfalls during postmortem evaluation.

Original languageEnglish (US)
Pages (from-to)58-66
Number of pages9
JournalAcademic Forensic Pathology
Issue number1
StatePublished - Mar 1 2012


  • Cause of death
  • Diagnosis-differential
  • Forensic pathology
  • Medical errors
  • Neuropathology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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