Rapid microwave-assisted deprotection of N-Cbz and N-Bn derivatives

Maria Caterina Daga; Maurizio Taddei; Greta Varchi

doi:10.1016/S0040-4039(01)00969-8

Rapid microwave-assisted deprotection of N-Cbz and N-Bn derivatives

Maria Caterina Daga, Maurizio Taddei, Greta Varchi

Houston Methodist

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Catalytic-transfer hydrogenation in iso-propanol under microwave irradiation has been performed to rapidly deprotect N-Cbz and N-Bn derivatives. The method is particularly suitable for the synthesis of short peptides and can also be carried out on supported molecules. The rapid cleavage of chiral molecules derived from (S)-1-phenylethylamine can be very useful for asymmetric synthesis of nitrogen containing compounds.

Original language	English (US)
Pages (from-to)	5191-5194
Number of pages	4
Journal	Tetrahedron Letters
Volume	42
Issue number	31
DOIs	https://doi.org/10.1016/S0040-4039(01)00969-8
State	Published - Jul 30 2001

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)00969-8

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title = "Rapid microwave-assisted deprotection of N-Cbz and N-Bn derivatives",

abstract = "Catalytic-transfer hydrogenation in iso-propanol under microwave irradiation has been performed to rapidly deprotect N-Cbz and N-Bn derivatives. The method is particularly suitable for the synthesis of short peptides and can also be carried out on supported molecules. The rapid cleavage of chiral molecules derived from (S)-1-phenylethylamine can be very useful for asymmetric synthesis of nitrogen containing compounds.",

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T1 - Rapid microwave-assisted deprotection of N-Cbz and N-Bn derivatives

AU - Daga, Maria Caterina

AU - Taddei, Maurizio

AU - Varchi, Greta

PY - 2001/7/30

Y1 - 2001/7/30

N2 - Catalytic-transfer hydrogenation in iso-propanol under microwave irradiation has been performed to rapidly deprotect N-Cbz and N-Bn derivatives. The method is particularly suitable for the synthesis of short peptides and can also be carried out on supported molecules. The rapid cleavage of chiral molecules derived from (S)-1-phenylethylamine can be very useful for asymmetric synthesis of nitrogen containing compounds.

AB - Catalytic-transfer hydrogenation in iso-propanol under microwave irradiation has been performed to rapidly deprotect N-Cbz and N-Bn derivatives. The method is particularly suitable for the synthesis of short peptides and can also be carried out on supported molecules. The rapid cleavage of chiral molecules derived from (S)-1-phenylethylamine can be very useful for asymmetric synthesis of nitrogen containing compounds.

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U2 - 10.1016/S0040-4039(01)00969-8

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M3 - Article

AN - SCOPUS:0035974355

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VL - 42

SP - 5191

EP - 5194

JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

Rapid microwave-assisted deprotection of N-Cbz and N-Bn derivatives

Abstract

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