Abstract
Catalytic-transfer hydrogenation in iso-propanol under microwave irradiation has been performed to rapidly deprotect N-Cbz and N-Bn derivatives. The method is particularly suitable for the synthesis of short peptides and can also be carried out on supported molecules. The rapid cleavage of chiral molecules derived from (S)-1-phenylethylamine can be very useful for asymmetric synthesis of nitrogen containing compounds.
Original language | English (US) |
---|---|
Pages (from-to) | 5191-5194 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 42 |
Issue number | 31 |
DOIs | |
State | Published - Jul 30 2001 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry