Rapid microwave-assisted deprotection of N-Cbz and N-Bn derivatives

Maria Caterina Daga, Maurizio Taddei, Greta Varchi

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Catalytic-transfer hydrogenation in iso-propanol under microwave irradiation has been performed to rapidly deprotect N-Cbz and N-Bn derivatives. The method is particularly suitable for the synthesis of short peptides and can also be carried out on supported molecules. The rapid cleavage of chiral molecules derived from (S)-1-phenylethylamine can be very useful for asymmetric synthesis of nitrogen containing compounds.

Original languageEnglish (US)
Pages (from-to)5191-5194
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number31
DOIs
StatePublished - Jul 30 2001

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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